Optimizing sensitivity and dynamic range of silicon photomultipliers for frequency-domain near infrared spectroscopy.
Journal
Biomedical optics express
ISSN: 2156-7085
Titre abrégé: Biomed Opt Express
Pays: United States
ID NLM: 101540630
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
01
07
2020
revised:
20
08
2020
accepted:
26
08
2020
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
6
10
2020
Statut:
epublish
Résumé
Diffuse optical imaging and tomography based upon frequency-domain near-infrared spectroscopy (fdNIRS) is used to noninvasively measure tissue structure and function through quantitative absolute measurements of tissue optical absorption and scattering. Here we describe how utilizing a silicon photomultiplier (SiPM) detector for fdNIRS improves performance. We discuss the operation of SiPMs, how they differ from other fdNIRS photodetectors, and show theoretically that SiPMs offer similar sensitivity to photomultiplier tube (PMT) detectors while having a higher dynamic range and lower cost, size, and operating voltage. With respect to avalanche photodiode (APD) detectors, theoretical and experimental data shows drastically increased signal to noise ratio performance, up to 25dB on human breast, head, and muscle tissue. Finally, we extend the dynamic range (∼10dB) of the SiPM through a nonlinear calibration technique which reduced absorption error by a mean 16 percentage points.
Identifiants
pubmed: 33014621
doi: 10.1364/BOE.401439
pii: 401439
pmc: PMC7510869
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5373-5387Informations de copyright
© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
Déclaration de conflit d'intérêts
VJK and TDO disclose patents related to fdNIRS technology. TDO discloses ownership of NearWave, Inc, which is producing a commercial fdNIRS device. VJK: University of Notre Dame (P), TDO: NearWave, Inc. (I, E, P)
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