Executive function and its relation to anatomical connectome in homosexual and heterosexual men.
Homosexual man
anatomical connectome
executive function
magnetic resonance imaging (MRI)
neuropsychological characteristic
Journal
Quantitative imaging in medicine and surgery
ISSN: 2223-4292
Titre abrégé: Quant Imaging Med Surg
Pays: China
ID NLM: 101577942
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
6
10
2020
Statut:
ppublish
Résumé
Sexual orientation has been suggested to affect executive function, of which the neurobiological basis is still largely unknown. In this study, we explored the interrelationship between neuropsychological characteristics in homosexual and heterosexual men and their anatomical connectome by graph theoretical analysis. Fifty-three homosexual and 47 heterosexual males underwent diffusion tensor magnetic resonance imaging (MRI) and neuropsychological assessments. Whole-brain anatomical networks were constructed using white matter tractography, performed on the diffusion tensor imaging data. Neuropsychological tests included the Wisconsin Card Sorting Test (WCST), the Continuous Performance Test (CPT) and the Trail-Making Test (TMT). The cognitive performance of homosexual men was significantly poorer than their heterosexual counterparts in terms of WCST total correct responses. Anatomical connectome analysis revealed a lower (P=0.001) anatomical connectivity between left PoCG and left SMG (P=0.003) in homosexual men as compared to heterosexual men. Linear regression analyses showed that the WCST total correct responses score was significantly linked with sexual orientation (P=0.001). The anatomical connectivity strength between left PoCG and left SMG was also shown to be significantly correlated with sexual orientation (P=0.039) and education (P=0.047). Our study demonstrated the differences in the performance of WCST and anatomical connectome of large-scale brain networks between homosexual and heterosexual men, extending our understanding of the brain's circuitry and the characteristics of executive function in men of different sexual orientation.
Sections du résumé
BACKGROUND
BACKGROUND
Sexual orientation has been suggested to affect executive function, of which the neurobiological basis is still largely unknown. In this study, we explored the interrelationship between neuropsychological characteristics in homosexual and heterosexual men and their anatomical connectome by graph theoretical analysis.
METHODS
METHODS
Fifty-three homosexual and 47 heterosexual males underwent diffusion tensor magnetic resonance imaging (MRI) and neuropsychological assessments. Whole-brain anatomical networks were constructed using white matter tractography, performed on the diffusion tensor imaging data. Neuropsychological tests included the Wisconsin Card Sorting Test (WCST), the Continuous Performance Test (CPT) and the Trail-Making Test (TMT).
RESULTS
RESULTS
The cognitive performance of homosexual men was significantly poorer than their heterosexual counterparts in terms of WCST total correct responses. Anatomical connectome analysis revealed a lower (P=0.001) anatomical connectivity between left PoCG and left SMG (P=0.003) in homosexual men as compared to heterosexual men. Linear regression analyses showed that the WCST total correct responses score was significantly linked with sexual orientation (P=0.001). The anatomical connectivity strength between left PoCG and left SMG was also shown to be significantly correlated with sexual orientation (P=0.039) and education (P=0.047).
CONCLUSIONS
CONCLUSIONS
Our study demonstrated the differences in the performance of WCST and anatomical connectome of large-scale brain networks between homosexual and heterosexual men, extending our understanding of the brain's circuitry and the characteristics of executive function in men of different sexual orientation.
Identifiants
pubmed: 33014729
doi: 10.21037/qims-19-821b
pii: qims-10-10-1973
pmc: PMC7495316
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1973-1983Commentaires et corrections
Type : CommentIn
Informations de copyright
2020 Quantitative Imaging in Medicine and Surgery. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/qims-19-821b). The authors have no conflicts of interest to declare.
Références
Neuroimage Clin. 2019;23:101852
pubmed: 31077981
Neuropsychology. 2003 Apr;17(2):240-6
pubmed: 12803429
Biophys J. 1994 Jan;66(1):259-67
pubmed: 8130344
J Theor Biol. 2004 Sep 21;230(2):173-87
pubmed: 15302549
Neuron. 2008 May 8;58(3):306-24
pubmed: 18466742
J Neurophysiol. 2006 Oct;96(4):1902-11
pubmed: 16738210
Neuropsychol Rev. 2006 Mar;16(1):17-42
pubmed: 16794878
Cortex. 1976 Dec;12(4):313-24
pubmed: 1009768
Psychol Bull. 1987 Mar;101(2):233-58
pubmed: 2882536
Ann Neurol. 1999 Feb;45(2):265-9
pubmed: 9989633
Cortex. 2017 Dec;97:339-357
pubmed: 29157936
Hum Brain Mapp. 2008 Jun;29(6):726-35
pubmed: 17636559
Brain. 2011 Oct;134(Pt 10):2912-28
pubmed: 21975588
Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2709-13
pubmed: 9482952
J Neurosci. 2008 Oct 29;28(44):11106-10
pubmed: 18971453
Annu Rev Clin Psychol. 2011;7:113-40
pubmed: 21128784
Nature. 1998 Jun 4;393(6684):440-2
pubmed: 9623998
Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9403-8
pubmed: 18559854
AJNR Am J Neuroradiol. 2008 Nov;29(10):1890-6
pubmed: 18768725
Ann Neurol. 1981 Oct;10(4):309-25
pubmed: 7032417
Nat Rev Neurosci. 2002 Mar;3(3):201-15
pubmed: 11994752
Psychoneuroendocrinology. 1991;16(6):459-73
pubmed: 1811244
Brain Cogn. 1986 Jul;5(3):280-90
pubmed: 3756005
J Sex Med. 2011 Nov;8(11):3132-43
pubmed: 21883951
J Psychiatry Neurosci. 2013 Jul;38(4):249-58
pubmed: 23171695
Nat Genet. 1995 Nov;11(3):248-56
pubmed: 7581447
Quant Imaging Med Surg. 2018 Nov;8(10):1020-1029
pubmed: 30598879
Neuroimage. 2006 Nov 15;33(3):825-33
pubmed: 16979350
Arch Sex Behav. 1991 Jun;20(3):307-18
pubmed: 2059149
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7821-6
pubmed: 12060727
Medicine (Baltimore). 2015 Oct;94(40):e1737
pubmed: 26448031
Nat Rev Neurosci. 2009 Mar;10(3):186-98
pubmed: 19190637
Brain Res. 2004 Oct 22;1024(1-2):251-4
pubmed: 15451388
J Consult Psychol. 1955 Oct;19(5):393-4
pubmed: 13263471
J Atten Disord. 2006 Feb;9(3):556-8
pubmed: 16481673
Science. 1993 Jul 16;261(5119):321-7
pubmed: 8332896
Hum Brain Mapp. 2015 May;36(5):1995-2013
pubmed: 25641208
J Neurosci. 2001 Oct 1;21(19):7733-41
pubmed: 11567063
Curr Opin Neurol. 2010 Aug;23(4):341-50
pubmed: 20581686
Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1929-34
pubmed: 23319644
Psychiatr Clin North Am. 2005 Sep;28(3):567-80, 578-9
pubmed: 16122567
Schizophr Res. 2013 Apr;145(1-3):1-10
pubmed: 23415471
J Child Neurol. 2015 Nov;30(13):1757-66
pubmed: 25862737
Behav Neurosci. 2005 Feb;119(1):311-6
pubmed: 15727535
Eur J Pharmacol. 2010 Jan 10;626(1):83-6
pubmed: 19835870
Science. 1999 Mar 12;283(5408):1657-61
pubmed: 10073923
J Gen Psychol. 1948 Jul;39:15-22
pubmed: 18889466
Cereb Cortex. 1991 Jan-Feb;1(1):62-79
pubmed: 1822726
Front Hum Neurosci. 2013 Feb 21;7:42
pubmed: 23439846
PLoS One. 2011;6(7):e21976
pubmed: 21818285
Am J Psychiatry. 2008 Apr;165(4):524-32
pubmed: 18281408
Science. 2007 Jun 15;316(5831):1612-5
pubmed: 17569863
Hum Genet. 2005 Mar;116(4):272-8
pubmed: 15645181
Quant Imaging Med Surg. 2018 Nov;8(10):1030-1038
pubmed: 30598880
Exp Brain Res. 2006 May;171(1):56-66
pubmed: 16307258