Chromatin and Transcriptional Response to Loss of TBX1 in Early Differentiation of Mouse Cells.
DiGeorge syndrome
TBX1
chromatin accessibility
embryonic stell cell
transcriptional response
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
06
2020
accepted:
18
08
2020
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
6
10
2020
Statut:
epublish
Résumé
The T-box transcription factor TBX1 has critical roles in the cardiopharyngeal lineage and the gene is haploinsufficient in DiGeorge syndrome, a typical developmental anomaly of the pharyngeal apparatus. Despite almost two decades of research, if and how TBX1 function triggers chromatin remodeling is not known. Here, we explored genome-wide gene expression and chromatin remodeling in two independent cellular models of
Identifiants
pubmed: 33015063
doi: 10.3389/fcell.2020.571501
pmc: PMC7505952
doi:
Types de publication
Journal Article
Langues
eng
Pagination
571501Informations de copyright
Copyright © 2020 Cirino, Aurigemma, Franzese, Lania, Righelli, Ferrentino, Illingworth, Angelini and Baldini.
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