Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline.
Alzheimer's disease
Retia
amyloid beta
brain volumetric analysis
confocal scanning ophthalmoscope
neurodegenerative disease
retina
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
06
2020
revised:
21
08
2020
accepted:
26
08
2020
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
6
10
2020
Statut:
epublish
Résumé
Despite advances in imaging retinal amyloidosis, a quantitative and topographical investigation of retinal amyloid beta burden in patients with cognitive decline has never been reported. We used the specific amyloid-binding fluorophore curcumin and laser ophthalmoscopy to assess retinal amyloid imaging (RAI) in 34 patients with cognitive decline. We automatically quantified retinal amyloid count (RAC) and area in the superotemporal retinal sub-regions and performed correlation analyses with cognitive and brain volumetric parameters. RAC significantly and inversely correlated with hippocampal volume (HV; r = -0.39, Quantitative RAI is a feasible technique and PMP RAC may predict HV. Future larger studies should determine RAI's potential as a biomarker of early AD.
Identifiants
pubmed: 33015311
doi: 10.1002/dad2.12109
pii: DAD212109
pmc: PMC7521595
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12109Subventions
Organisme : NIA NIH HHS
ID : R01 AG055865
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056478
Pays : United States
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
Keith L. Black, Steven Verdooner, Yosef Koronyo, and Maya Koronyo‐Hamaoui are co‐founding members of NeuroVision Imaging Inc. Keith L. Black, Steven Verdooner, and Czeszynski Alan D are in leading roles in NeuroVision Imaging Inc. Keith L. Black, Steven Verdooner, Yosef Koronyo, and Maya Koronyo‐Hamaoui are co‐inventors of US patents related to retinal imaging and Alzheimer's disease. Sally Frautschy is co‐inventor on US patent US9192644B2 for a curcumin formulation and is a co‐founding member of Optimized Curcumin Longvida. Other authors declare no conflict.
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