Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis.
ALR, adiponectin-to-leptin ratio
ATX, autotaxin
ATX-apo(a), ATX carried by Lp(a)
ATX-apoB, ATX carried by apoB-containing lipoproteins
BMI, body mass index
CAD, coronary artery disease
CAVS, calcific aortic valve stenosis
HDL, high-density lipoprotein
LDL, low-density lipoprotein
Lp(a), lipoprotein(a)
LysoPA, lysophosphatidic acid
LysoPC, lysophosphatidylcholine
OxPLs, oxidized phospholipids
apo(a), apolipoprotein(a)
apoB, apolipoprotein B
autotaxin
calcific aortic valve stenosis
lipoprotein(a)
low-density lipoproteins
obesity
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
20
03
2020
revised:
22
06
2020
accepted:
23
06
2020
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
6
10
2020
Statut:
epublish
Résumé
Our objectives were to determine whether autotaxin (ATX) is transported by lipoprotein(a) [Lp(a)] in human plasma and if could be used as a biomarker of calcific aortic valve stenosis (CAVS). We first found that ATX activity was higher in Lp(a) compared to low-density lipoprotein fractions in isolated fractions of 10 healthy participants. We developed a specific assay to measure ATX-Lp(a) in 88 patients with CAVS and 144 controls without CAVS. In a multivariable model corrected for CAVS risk factors, ATX-Lp(a) was associated with CAVS (p = 0.003). We concluded that ATX is preferentially transported by Lp(a) and might represent a novel biomarker for CAVS.
Identifiants
pubmed: 33015412
doi: 10.1016/j.jacbts.2020.06.012
pii: S2452-302X(20)30303-X
pmc: PMC7524777
doi:
Types de publication
Journal Article
Langues
eng
Pagination
888-897Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Authors.
Références
J Am Coll Cardiol. 2015 Sep 15;66(11):1236-1246
pubmed: 26361154
J Am Coll Cardiol. 2017 Feb 14;69(6):692-711
pubmed: 28183512
J Am Coll Cardiol. 1997 Mar 1;29(3):630-4
pubmed: 9060903
Eur Heart J. 2003 Jan;24(2):198-208
pubmed: 12573277
Chem Res Toxicol. 2011 Jan 14;24(1):111-8
pubmed: 20973507
Curr Opin Cardiol. 2018 Mar;33(2):125-133
pubmed: 29194051
J Intern Med. 2016 Nov;280(5):509-517
pubmed: 27237700
Nat Rev Dis Primers. 2016 Mar 03;2:16006
pubmed: 27188578
Can J Cardiol. 2014 Sep;30(9):982-93
pubmed: 25085215
Biochim Biophys Acta. 2008 Sep;1781(9):513-8
pubmed: 18621144
Circ Cardiovasc Genet. 2014 Jun;7(3):304-10
pubmed: 24704946
J Am Coll Cardiol. 2014 Feb 11;63(5):470-7
pubmed: 24161338
J Am Coll Cardiol. 2019 May 7;73(17):2150-2162
pubmed: 31047003
N Engl J Med. 2013 Feb 7;368(6):503-12
pubmed: 23388002
Biochemistry. 1991 May 21;30(20):5044-51
pubmed: 2036372
Br J Pharmacol. 2012 Oct;167(3):465-82
pubmed: 22568609
Expert Rev Cardiovasc Ther. 2017 Oct;15(10):797-807
pubmed: 28816078
Cardiovasc Res. 2017 Sep 1;113(11):1351-1363
pubmed: 28472283
Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6931-6
pubmed: 10359816
Circulation. 2000 Feb 22;101(7):765-71
pubmed: 10683350
Physiol Rep. 2019 Mar;7(5):e14004
pubmed: 30821134
J Biol Chem. 2002 Oct 18;277(42):39436-42
pubmed: 12176993
J Am Coll Cardiol. 2014 Jun 10;63(22):e57-185
pubmed: 24603191
J Am Coll Cardiol. 2005 Jul 19;46(2):291-8
pubmed: 16022957
Circulation. 2015 Aug 25;132(8):677-90
pubmed: 26224810
Circulation. 1994 Aug;90(2):844-53
pubmed: 7519131
Biochimie. 2014 Jan;96:140-3
pubmed: 23639740
N Engl J Med. 2000 Aug 31;343(9):611-7
pubmed: 10965007
Nat Rev Cancer. 2003 Aug;3(8):582-91
pubmed: 12894246
J Biol Chem. 1992 Feb 5;267(4):2524-9
pubmed: 1733949
J Lipid Res. 2011 Jun;52(6):1247-55
pubmed: 21421848
JACC Basic Transl Sci. 2017 Jun;2(3):229-240
pubmed: 29147686
Proc Natl Acad Sci U S A. 1984 Jun;81(12):3883-7
pubmed: 6587396
J Biol Chem. 2003 Jun 27;278(26):23260-9
pubmed: 12697748
J Lipid Res. 2017 Nov;58(11):2102-2113
pubmed: 28874440
J Physiol Biochem. 2012 Dec;68(4):635-44
pubmed: 22644624