Afferent renal innervation in anti-Thy1.1 nephritis in rats.

Afferent Pathways / drug effects Animals Calcitonin Gene-Related Peptide / pharmacology Kidney / drug effects Nephritis / drug therapy Neurons / drug effects Neurons, Afferent / drug effects Rats, Sprague-Dawley Substance P / metabolism
afferent renal neerves calcitonin gene-related peptide renal inflammation renal innervation sympathetic innervation

Journal

American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990

Informations de publication

Date de publication:
01 11 2020
Historique:
pubmed: 6 10 2020
medline: 15 12 2020
entrez: 5 10 2020
Statut: ppublish

Résumé

Afferent renal nerves exhibit a dual function controlling central sympathetic outflow via afferent electrical activity and influencing intrarenal immunological processes by releasing peptides such as calcitonin gene-related peptide (CGRP). We tested the hypothesis that increased afferent and efferent renal nerve activity occur with augmented release of CGRP in anti-Thy1.1 nephritis, in which enhanced CGRP release exacerbates inflammation. Nephritis was induced in Sprague-Dawley rats by intravenous injection of OX-7 antibody (1.75 mg/kg), and animals were investigated neurophysiologically, electrophysiologically, and pathomorphologically 6 days later. Nephritic rats exhibited proteinuria (169.3 ± 10.2 mg/24 h) with increased efferent renal nerve activity (14.7 ± 0.9 bursts/s vs. control 11.5 ± 0.9 bursts/s,

Identifiants

DOI: 10.1152/ajprenal.00063.2020 PMID: 33017188
pubmed: 33017188
doi: 10.1152/ajprenal.00063.2020
doi:

Substances chimiques

Substance P 33507-63-0
Calcitonin Gene-Related Peptide JHB2QIZ69Z

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

F822-F832

Auteurs

Kristina Rodionova (K)

Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, Germany.

Roland Veelken (R)

Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, Germany.
Department of Internal Medicine 4 (Nephrology und Hypertension), Paracelsus Private Medical School, Klinikum Nuremberg, Nuremberg, Germany.

Karl F Hilgers (KF)

Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, Germany.

Eva-Maria Paulus (EM)

Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, Germany.

Peter Linz (P)

Department of Radiology, University of Erlangen, Erlangen, Germany.

Michael J M Fischer (MJM)

Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0002-3811-7066

Martina Schenker (M)

Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, Germany.
Department of Physiology and Pathophysiology, University Erlangen, Erlangen, Germany.

Peter Reeh (P)

Department of Physiology and Pathophysiology, University Erlangen, Erlangen, Germany.
ORCID: 0000-0002-4367-094X

Gisa Tiegs (G)

Center of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Christian Ott (C)

Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, Germany.
Department of Internal Medicine 4 (Nephrology und Hypertension), Paracelsus Private Medical School, Klinikum Nuremberg, Nuremberg, Germany.

Roland Schmieder (R)

Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, Germany.

Mario Schiffer (M)

Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, Germany.

Kerstin Amann (K)

Department of Nephropathology, University of Erlangen, Erlangen, Germany.

Tilmann Ditting (T)

Department of Internal Medicine 4 (Nephrology und Hypertension), University of Erlangen, Erlangen, Germany.
Department of Internal Medicine 4 (Nephrology und Hypertension), Paracelsus Private Medical School, Klinikum Nuremberg, Nuremberg, Germany.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Voies nerveuses › Voies afférentes › Afferent renal innervation in anti-Thy1.1...
questionsmedicales.fr › Eucaryotes › Animaux › Afferent renal innervation in anti-Thy1.1...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Peptide relié au gène de la calcitonine › Afferent renal innervation in anti-Thy1.1...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Afferent renal innervation in anti-Thy1.1...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Néphrite › Afferent renal innervation in anti-Thy1.1...
questionsmedicales.fr › Cellules › Neurones › Afferent renal innervation in anti-Thy1.1...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Afferent renal innervation in anti-Thy1.1...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Afferent renal innervation in anti-Thy1.1...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Kinines › Tachykinines › Substance P › Afferent renal innervation in anti-Thy1.1...