International consensus validation of the POPI tool (Pediatrics: Omission of Prescriptions and Inappropriate prescriptions) to identify inappropriate prescribing in pediatrics.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
04
2020
accepted:
19
09
2020
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
15
12
2020
Statut:
epublish
Résumé
While drug prescription should be based on established recommendations stemming from clinical trials but in pediatrics, many drugs are used without marketing authorization. Consequently recommendations are often based on clinical experience and the risk of inappropriate prescription (IP) is high. A tool for detecting IP in pediatrics-called POPI (Pediatrics: Omission of Prescriptions and Inappropriate prescriptions)-has been developed in France. However the relevance of its use at an international level is not known. Our aim has been to adapt POPI for a worldwide use. A two-round Delphi online questionnaire was completed and validated by international experts to identify consensual items. They were asked to rate the validity of each items taking into account the recommendations and practices in their countries. Only propositions obtaining a median score in the upper tertile with an agreement of more than 75% of the panel-for the first round-and 85%-for the second round-were retained. Our panel included 11 pharmacists (55%) and 9 physicians (45%). The panelists came from 12 different countries: England, Belgium, Brazil, Canada, China, Ivory Coast, Ireland, Malaysia, Portugal, Switzerland, Turkey and Vietnam. At the end of the first round, of the 105 items of the original POPI tool, 80 items were retained including 16 items reworded and 25 items were deleted. In the second round, 14 experts participated in the study. This final international POPI tool is composed of 73 IP and omissions of prescriptions in the fields of neuropsychiatry, dermatology, infectiology, pneumology, gastroenterology, pain and fever. This study highlights international consensus on prescription practice in pediatrics. The use of this tool in everyday practice could reduce the risk of inappropriate prescription. The impact of the diffusion of POPI tool will be assessed in a prospective multicentric study.
Identifiants
pubmed: 33017423
doi: 10.1371/journal.pone.0240105
pii: PONE-D-20-10812
pmc: PMC7535059
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0240105Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Int J Clin Pharm. 2019 Jun;41(3):734-740
pubmed: 30972535
Eur J Clin Pharmacol. 2018 May;74(5):627-636
pubmed: 29290074
J Cardiovasc Pharmacol. 2013 Mar;61(3):218-25
pubmed: 23188128
J Clin Pharmacol. 2008 Mar;48(3):379-84
pubmed: 18223146
Eur J Emerg Med. 2005 Jun;12(3):117-9
pubmed: 15891443
J Am Geriatr Soc. 2019 Apr;67(4):674-694
pubmed: 30693946
BMJ Open. 2016 Sep 06;6(9):e012079
pubmed: 27601499
Arch Pediatr Adolesc Med. 2007 Mar;161(3):282-90
pubmed: 17339510
Indian J Pediatr. 2016 May;83(5):414-9
pubmed: 26916890
Arch Intern Med. 1989 Nov;149(11):2486-92
pubmed: 2684075
Can J Hosp Pharm. 2016 May-Jun;69(3):224-30
pubmed: 27403002
Br J Clin Pharmacol. 2001 Jul;52(1):77-83
pubmed: 11453893
Age Ageing. 2009 Sep;38(5):603-6
pubmed: 19435757
Eur J Epidemiol. 2010 Aug;25(8):593-601
pubmed: 20563834
Age Ageing. 2008 Nov;37(6):673-9
pubmed: 18829684
Healthcare (Basel). 2019 Feb 20;7(1):
pubmed: 30791668
BMC Med. 2013 Nov 07;11:237
pubmed: 24228998
J Urol. 2004 Aug;172(2):448-53
pubmed: 15247700
Clin Pharmacol Ther. 2011 Jun;89(6):845-54
pubmed: 21508941
J Am Geriatr Soc. 2012 Apr;60(4):616-31
pubmed: 22376048
BMJ Open. 2019 Mar 20;9(3):e019186
pubmed: 30898791
PLoS One. 2014 Jun 30;9(6):e101171
pubmed: 24978045
Am J Public Health. 1984 Sep;74(9):979-83
pubmed: 6380323
Pediatrics. 2018 Mar;141(3):
pubmed: 30352389