Pharmacologic Approach to Sinoatrial Node Dysfunction.
Cav1.3
G protein–activated K+ channels
SAN
ankyrin-B
sinoatrial node dysfunction
tertiapin-Q
Journal
Annual review of pharmacology and toxicology
ISSN: 1545-4304
Titre abrégé: Annu Rev Pharmacol Toxicol
Pays: United States
ID NLM: 7607088
Informations de publication
Date de publication:
06 01 2021
06 01 2021
Historique:
pubmed:
6
10
2020
medline:
10
9
2021
entrez:
5
10
2020
Statut:
ppublish
Résumé
The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis of the heart pacemaker tissue. However, other forms of SND exist, including idiopathic primary SND, which is genetic, and forms that are secondary to cardiovascular or systemic disease. The incidence of SND in the general population is expected to increase over the next half century, boosting the need to implant electronic pacemakers. During the last two decades, our knowledge of sino-atrial node physiology and of the pathophysiological mechanisms underlying SND has advanced considerably. This review summarizes the current knowledge about SND mechanisms and discusses the possibility of introducing new pharmacologic therapies for treating SND.
Identifiants
pubmed: 33017571
doi: 10.1146/annurev-pharmtox-031120-115815
pmc: PMC7790915
mid: NIHMS1636884
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
757-778Subventions
Organisme : NHLBI NIH HHS
ID : R35 HL135754
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL115580
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134824
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135109
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135096
Pays : United States
Références
Circ Arrhythm Electrophysiol. 2010 Oct;3(5):542-52
pubmed: 20693575
JAMA. 1968 Oct 14;206(3):645-6
pubmed: 5695590
Circulation. 2014 Jul 22;130(4):315-24
pubmed: 24838362
Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E3037-46
pubmed: 23878236
Circulation. 2003 Aug 12;108(6):760-6
pubmed: 12885752
Biochemistry. 1999 Oct 26;38(43):14286-93
pubmed: 10572003
J Arrhythm. 2016 Oct;32(5):352-358
pubmed: 27761158
Circulation. 2009 Mar 31;119(12):1562-75
pubmed: 19289639
Crit Care Med. 2008 Nov;36(11):3014-8
pubmed: 18824911
Eur Heart J. 2013 Dec;34(47):3624-31
pubmed: 23756332
Am J Hum Genet. 2016 Sep 1;99(3):704-710
pubmed: 27523599
J Am Coll Cardiol. 2012 Oct 16;60(16):1540-5
pubmed: 22999727
J Clin Invest. 2012 Mar;122(3):1119-30
pubmed: 22354168
Circ Cardiovasc Genet. 2010 Aug;3(4):374-85
pubmed: 20562447
Nat Commun. 2019 Jun 28;10(1):2889
pubmed: 31253831
Purinergic Signal. 2019 Mar;15(1):45-52
pubmed: 30535950
Circ Res. 2017 Aug 18;121(5):549-563
pubmed: 28674041
J Clin Invest. 2003 May;111(10):1537-45
pubmed: 12750403
Biophys J. 1999 Mar;76(3):1310-9
pubmed: 10049314
Cardiovasc Res. 2000 Sep;47(4):658-87
pubmed: 10974216
Sci Rep. 2018 Mar 16;8(1):4670
pubmed: 29549309
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E932-41
pubmed: 26831068
J Mol Cell Cardiol. 2015 Jun;83:88-100
pubmed: 25668431
J Cardiovasc Electrophysiol. 1997 Aug;8(8):847-53
pubmed: 9261710
J Cardiovasc Pharmacol. 1998 Apr;31(4):534-9
pubmed: 9554801
Nat Neurosci. 2011 Jan;14(1):77-84
pubmed: 21131953
J Heart Lung Transplant. 1995 May-Jun;14(3):429-35
pubmed: 7654727
J Physiol. 2004 Sep 15;559(Pt 3):835-48
pubmed: 15254155
Annu Rev Physiol. 2020 Feb 10;82:21-43
pubmed: 31756134
Curr Pharm Des. 2003;9(28):2289-302
pubmed: 14529391
Nat Genet. 2011 Mar 06;43(4):316-20
pubmed: 21378987
Heart Rhythm. 2013 Nov;10(11):1683-9
pubmed: 23954346
J Cardiovasc Electrophysiol. 2006 Apr;17(4):446-55
pubmed: 16643374
Circulation. 2005 Sep 27;112(13):1936-44
pubmed: 16172271
Sci Rep. 2020 Jun 17;10(1):9835
pubmed: 32555258
Can J Cardiol. 2017 Jun;33(6):758-767
pubmed: 28545623
Circulation. 2016 May 10;133(19):1892-900
pubmed: 27166347
J Hum Genet. 2019 Feb;64(2):153-160
pubmed: 30498240
Eur J Clin Invest. 2013 Sep;43(9):957-63
pubmed: 23834267
J Physiol. 2009 Mar 1;587(Pt 5):1087-100
pubmed: 19139040
J Mol Cell Cardiol. 1992 Jun;24(6):567-78
pubmed: 1518074
J Am Coll Cardiol. 2014 Aug 26;64(8):757-67
pubmed: 25145518
Circ Res. 1999 Jul 9;85(1):e1-6
pubmed: 10400919
J Am Coll Cardiol. 1996 Aug;28(2):396-9
pubmed: 8800116
Circulation. 2005 Jun 14;111(23):3034-41
pubmed: 15939813
Circ Res. 2014 Mar 28;114(7):1103-13
pubmed: 24563458
Circ Res. 2015 Jun 5;116(12):1919-36
pubmed: 26044248
Nat Rev Cardiol. 2009 May;6(5):337-48
pubmed: 19377496
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15617-22
pubmed: 18832177
Nat Commun. 2014 May 13;5:3775
pubmed: 24825544
J Am Coll Cardiol. 1987 Jan;9(1):45-52
pubmed: 3794110
Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1219-27
pubmed: 26304511
J Physiol. 1994 Feb 1;474(3):473-82
pubmed: 7516974
Prog Biophys Mol Biol. 2016 Jan;120(1-3):164-78
pubmed: 26743207
Br Heart J. 1971 Sep;33(5):639-42
pubmed: 5115008
Circulation. 2016 Apr 5;133(14):e506-74
pubmed: 26399663
Europace. 2011 Aug;13(8):1077-109
pubmed: 21810866
Circulation. 2007 Oct 2;116(14):1569-76
pubmed: 17875969
Am J Cardiol. 1998 Nov 15;82(10):1205-9
pubmed: 9832095
Circulation. 2016 Aug 9;134(6):486-98
pubmed: 27462069
N Engl J Med. 2000 Mar 9;342(10):703-9
pubmed: 10706901
Circ Genom Precis Med. 2019 Jan;12(1):e002238
pubmed: 30645171
Eur Heart J. 2013 Aug;34(29):2281-329
pubmed: 23801822
Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):18011-6
pubmed: 24128759
Eur Heart J. 2007 Oct;28(20):2472-8
pubmed: 17823213
Circulation. 2011 Mar 8;123(9):1010-20
pubmed: 21382903
N Engl J Med. 2006 Jan 12;354(2):151-7
pubmed: 16407510
Pacing Clin Electrophysiol. 2010 Nov;33(11):1392-406
pubmed: 20946278
EMBO Mol Med. 2017 Apr;9(4):415-429
pubmed: 28219898
Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3507-12
pubmed: 12631690
J Cardiovasc Pharmacol Ther. 2000 Jul;5(3):183-91
pubmed: 11150407
J Physiol. 2017 Jun 15;595(12):3847-3865
pubmed: 28346695
Circ Res. 2006 Jun 9;98(11):1422-30
pubmed: 16690884
Am J Emerg Med. 1999 Nov;17(7):647-52
pubmed: 10597081
Circulation. 1975 Oct;52(4):627-33
pubmed: 1157275
JCI Insight. 2017 Apr 20;2(8):
pubmed: 28422759
Circ Res. 2002 May 17;90(9):981-7
pubmed: 12016264
Circ Res. 2008 Feb 29;102(4):465-71
pubmed: 18096820
Front Physiol. 2015 Feb 12;6:37
pubmed: 25729366
Circulation. 1998 Apr 28;97(16):1623-31
pubmed: 9593568
Circulation. 1981 Apr;63(4):953-60
pubmed: 7471352
Circulation. 1997 Mar 18;95(6):1363-5
pubmed: 9118500
J Mol Cell Cardiol. 2005 Jun;38(6):969-81
pubmed: 15910881
J Am Coll Cardiol. 2002 Mar 20;39(6):1033-8
pubmed: 11897447
Nat Genet. 2013 Jun;45(6):621-31
pubmed: 23583979
Eur Heart J. 2015 Mar 14;36(11):686-97
pubmed: 24216388
J Mol Cell Cardiol. 1989 Apr;21(4):407-18
pubmed: 2746661
Nature. 1991 May 9;351(6322):145-7
pubmed: 1709448
Am J Cardiol. 1976 Jan;37(1):68-72
pubmed: 1244735
Circ Res. 2010 Feb 19;106(3):434-46
pubmed: 20167941
J Physiol. 2016 Oct 15;594(20):5869-5879
pubmed: 27374078
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5543-8
pubmed: 12700358
Br J Clin Pharmacol. 2016 Mar;81(3):453-61
pubmed: 26344579
Circ Res. 2010 Mar 5;106(4):659-73
pubmed: 20203315
Br J Pharmacol. 2000 Oct;131(3):569-77
pubmed: 11015309
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1705-10
pubmed: 21220308
Circulation. 2009 Mar 31;119(12):1576-85
pubmed: 19289641
Circulation. 2019 Apr 30;139(18):2157-2169
pubmed: 30764634
Cardiovasc Res. 2020 Jul 15;116(9):1557-1570
pubmed: 32251506
Circulation. 1988 Jun;77(6):1221-37
pubmed: 3370764
Physiology (Bethesda). 2013 Mar;28(2):74-92
pubmed: 23455768
Ann Pharmacother. 1995 Mar;29(3):269-81
pubmed: 7606074
Am J Physiol Heart Circ Physiol. 2014 Nov 1;307(9):H1327-38
pubmed: 25172903
PLoS One. 2014 Oct 06;9(10):e109662
pubmed: 25285853
JACC Basic Transl Sci. 2018 Dec 05;3(6):824-843
pubmed: 30623142
J Clin Invest. 2011 Aug;121(8):3277-88
pubmed: 21785215
Cardiovasc Res. 2007 Feb 1;73(3):531-8
pubmed: 17188667
J Am Coll Cardiol. 2014 Aug 12;64(6):531-8
pubmed: 25104519
Br Heart J. 1989 Feb;61(2):155-60
pubmed: 2923752
PLoS One. 2014 Dec 22;9(12):e115256
pubmed: 25531103
Circulation. 2006 Nov 14;114(20):2104-12
pubmed: 17060380
J Clin Invest. 2003 Oct;112(7):1019-28
pubmed: 14523039
Am Fam Physician. 2003 Apr 15;67(8):1725-32
pubmed: 12725451
Am J Physiol Heart Circ Physiol. 2012 May 1;302(9):H1773-83
pubmed: 22268110
Adv Cardiol. 2006;42:175-197
pubmed: 16646591
Cardiovasc Res. 2005 Jun 1;66(3):472-81
pubmed: 15914112
Cardiovasc Res. 2014 Apr 1;102(1):166-75
pubmed: 24445605
Life Sci. 2020 Jan 1;240:117068
pubmed: 31751583
J Physiol. 2005 Sep 1;567(Pt 2):387-400
pubmed: 15932895
Circulation. 2013 Jul 9;128(2):101-14
pubmed: 23734001
EMBO J. 2007 Oct 31;26(21):4423-32
pubmed: 17914461
J Mol Cell Cardiol. 2011 Jan;50(1):194-202
pubmed: 20951705
Circulation. 1976 May;53(5):763-76
pubmed: 1260979
Heart Rhythm. 2013 Jan;10(1):110-8
pubmed: 22985657
Circulation. 2005 Feb 22;111(7):846-54
pubmed: 15699261
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):E1685-94
pubmed: 23589888
Am Heart J. 1977 Jun;93(6):735-40
pubmed: 871100
J Am Heart Assoc. 2016 Apr 20;5(4):e002865
pubmed: 27098968
Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9769-74
pubmed: 26195795
Trends Cardiovasc Med. 2000 Apr;10(3):114-22
pubmed: 11427998
Front Genet. 2019 Jul 11;10:648
pubmed: 31354791
J Am Coll Cardiol. 2019 Aug 20;74(7):932-987
pubmed: 30412710
N Engl J Med. 1982 Nov 25;307(22):1357-62
pubmed: 6752715
Nat Genet. 1999 Sep;23(1):20-1
pubmed: 10471492
Geriatrics. 1990 Jan;45(1):26-30, 33-6
pubmed: 2403955
PLoS One. 2013 Sep 09;8(9):e72668
pubmed: 24039792
Neuron. 1998 Jan;20(1):103-14
pubmed: 9459446
Clin Toxicol (Phila). 2014 Nov;52(9):926-44
pubmed: 25283255
Circ Res. 2017 May 12;120(10):e33-e44
pubmed: 28219978
Eur J Biochem. 1976 Jan 15;61(2):369-76
pubmed: 1248464
Cell. 2000 Jul 7;102(1):89-97
pubmed: 10929716
Cardiovasc Res. 2016 Mar 1;109(3):451-61
pubmed: 26786159
J Pharmacol Exp Ther. 2000 Apr;293(1):196-205
pubmed: 10734170
J Mol Med (Berl). 2005 Jan;83(1):79-83
pubmed: 15551023
Am Heart J. 2000 Oct;140(4):541-51
pubmed: 11011325
Nat Commun. 2014 Aug 21;5:4664
pubmed: 25144323
J Cardiol. 2019 Oct;74(4):328-332
pubmed: 30982679
J Am Coll Cardiol. 2014 Aug 26;64(8):745-56
pubmed: 25145517
Anesth Analg. 2005 Dec;101(6):1809-11
pubmed: 16301263
Annu Rev Med. 1979;30:91-118
pubmed: 400510
J Mol Cell Cardiol. 2001 Jun;33(6):1153-63
pubmed: 11444920
J Clin Invest. 2013 Mar;123(3):1262-74
pubmed: 23426181
Circ Res. 1995 May;76(5):802-11
pubmed: 7728997
Am J Cardiol. 1991 Jun 1;67(15):1180-4
pubmed: 2035437
Circ Res. 2007 Jun 8;100(11):1605-14
pubmed: 17478725
Channels (Austin). 2011 May-Jun;5(3):251-61
pubmed: 21406960
J Physiol. 1996 Apr 1;492 ( Pt 1):21-30
pubmed: 8730579
Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H945-63
pubmed: 21724866
Circulation. 2012 Jul 24;126(4):392-401
pubmed: 22711277
Br Heart J. 1967 Jul;29(4):469-89
pubmed: 6029120
Nat Commun. 2020 Jan 24;11(1):512
pubmed: 31980605
Physiol Rev. 2008 Jul;88(3):919-82
pubmed: 18626064
J Emerg Med. 2001 Feb;20(2):145-52
pubmed: 11207409
Cardiovasc Res. 2001 Oct;52(1):40-50
pubmed: 11557232
Circ Res. 2017 Oct 13;121(9):1058-1068
pubmed: 28821541
J Med Genet. 2005 Nov;42(11):863-70
pubmed: 16272262
Cardiol Rev. 2004 Mar-Apr;12(2):65-8
pubmed: 14766019
Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):E154-63
pubmed: 22203979
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15235-40
pubmed: 14657344
Circulation. 2013 Dec 17;128(24):2585-94
pubmed: 24218458
Circ Res. 2003 May 16;92(9):976-83
pubmed: 12676817
Biochemistry. 1998 Sep 22;37(38):13291-9
pubmed: 9748337
Eur Heart J Cardiovasc Imaging. 2017 May 1;18(8):862-869
pubmed: 28087602
Biochim Biophys Acta. 2014 Oct;1843(10):2322-33
pubmed: 24613282
Nat Genet. 2010 Feb;42(2):117-22
pubmed: 20062063
Sci Transl Med. 2017 Jul 26;9(400):
pubmed: 28747516
Circ Res. 2002 Oct 18;91(8):e21-6
pubmed: 12386154