Eosinophils adhesion assay as a tool for phenotypic drug screening - The pharmacology of 1,3,5 - Triazine and 1H-indole like derivatives against the human histamine H
Animals
Anti-Inflammatory Agents
/ administration & dosage
Cell Adhesion
/ drug effects
Cell Line, Transformed
Cell Line, Tumor
Cell Membrane Permeability
/ drug effects
Cell Survival
/ drug effects
Computer Simulation
Croton Oil
/ toxicity
Disease Models, Animal
Drug Discovery
Drug Evaluation, Preclinical
Edema
/ chemically induced
Endothelial Cells
/ metabolism
Eosinophils
/ drug effects
Humans
Indoles
/ administration & dosage
Male
Mice
Pruritus
/ chemically induced
Receptors, Histamine H4
/ antagonists & inhibitors
Triazines
/ administration & dosage
1,3,5 – Triazine derivatives
1H-Indole like derivatives
1H-indole like derivatives
Adhesion
Endothelium
Eosinophils
Histamine
Histamine receptors
JN-25 (4-[(E)-2-(3-chlorophenyl)ethenyl]-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine)
JN-35 (4-(4-methylpiperazin-1-yl)-6-(3-phenylpropyl)-1,3,5-triazin-2-amine)
JNJ10191584 (5-chloro-1H-benzo[d]imidazol-2-yl)(4-methylpiperazin-1-yl)methanone) Pub- Chem CID: 10446295)
JNJ7777120 (5-chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone) Pub- Chem CID: 4908365)
KP-9D (2-(4-chlorophenyl)-4-(4-methylpiperazin-1-yl)-1,3,5-triazine)
MWJ-3 (5-chloro-7-nitro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone Pub- Chem CID: 70692530)
TR-18 (4-(4-bromophenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine)
TR-7 (4-(4-chlorophenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine)
TR-AF-45 (4-(4-methylpiperazin-1-yl)-6-neopentyl-1,3,5-triazin-2-amine)
TR-AF-49 (4-(cyclohexylmethyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine)
TR-DL-20 (4-(1-cyclohexenylmethyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine)
Journal
European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354
Informations de publication
Date de publication:
05 Jan 2021
05 Jan 2021
Historique:
received:
17
06
2020
revised:
22
09
2020
accepted:
28
09
2020
pubmed:
6
10
2020
medline:
8
6
2021
entrez:
5
10
2020
Statut:
ppublish
Résumé
Histamine is a pleiotropic biogenic amine, having affinity towards four distinct histamine receptors. The existing pharmacological studies suggest the usefulness of histamine H
Identifiants
pubmed: 33017589
pii: S0014-2999(20)30703-2
doi: 10.1016/j.ejphar.2020.173611
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
HRH4 protein, human
0
Indoles
0
Receptors, Histamine H4
0
Triazines
0
Croton Oil
8001-28-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173611Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.