Responsiveness of Retinal Ganglion Cells Through Frequency Modulation of Electrical Stimulation: A Computational Modeling Study
Journal
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
ISSN: 2694-0604
Titre abrégé: Annu Int Conf IEEE Eng Med Biol Soc
Pays: United States
ID NLM: 101763872
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
entrez:
6
10
2020
pubmed:
7
10
2020
medline:
24
10
2020
Statut:
ppublish
Résumé
Electrical stimulation of surviving retinal neurons has proven effective in restoring sight to totally blind patients affected by retinal degenerative diseases. Morphological and biophysical differences among retinal ganglion cells (RGCs) are important factors affecting their response to epiretinal electrical stimulation. Although detailed models of ON and OFF RGCs have already been investigated, here we developed morphologically and biophysically realistic computational models of two classified RGCs, D1-bistratified and A2-monostratified, and analyzed their response to alternations in stimulation frequency (up to 200 Hz). Results show that the D1-bistratified cell is more responsive to high frequency stimulation compared to the A2-monostratified cell. This differential RGCs response suggests a potential avenue for selective activation, and in turn different encoded percept of RGCs.
Identifiants
pubmed: 33018732
doi: 10.1109/EMBC44109.2020.9176125
pmc: PMC7997733
mid: NIHMS1679555
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3393-3398Subventions
Organisme : NEI NIH HHS
ID : R21 EY028744
Pays : United States
Organisme : NIBIB NIH HHS
ID : U01 EB025830
Pays : United States
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