Mast Cells in the Auditory Periphery of Rodents.
auditory periphery
cochlea
mast cell
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
01 Oct 2020
01 Oct 2020
Historique:
received:
01
09
2020
revised:
24
09
2020
accepted:
25
09
2020
entrez:
6
10
2020
pubmed:
7
10
2020
medline:
7
10
2020
Statut:
epublish
Résumé
Mast cells (MCs) are densely granulated cells of myeloid origin and are a part of immune and neuroimmune systems. MCs have been detected in the endolymphatic sac of the inner ear and are suggested to regulate allergic hydrops. However, their existence in the cochlea has never been documented. In this work, we show that MCs are present in the cochleae of C57BL/6 mice and Wistar rats, where they localize in the modiolus, spiral ligament, and stria vascularis. The identity of MCs was confirmed in cochlear cryosections and flat preparations using avidin and antibodies against c-Kit/CD117, chymase, tryptase, and FcεRIα. The number of MCs decreased significantly during postnatal development, resulting in only a few MCs present in the flat preparation of the cochlea of a rat. In addition, exposure to 40 µM cisplatin for 24 h led to a significant reduction in cochlear MCs. The presence of MCs in the cochlea may shed new light on postnatal maturation of the auditory periphery and possible involvement in the ototoxicity of cisplatin. Presented data extend the current knowledge about the physiology and pathology of the auditory periphery. Future functional studies should expand and translate this new basic knowledge to clinics.
Identifiants
pubmed: 33019672
pii: brainsci10100697
doi: 10.3390/brainsci10100697
pmc: PMC7601519
pii:
doi:
Types de publication
Journal Article
Langues
eng
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