The role of aspirin in the prevention of ovarian, endometrial and cervical cancers.
Anti-Inflammatory Agents, Non-Steroidal
/ therapeutic use
Antineoplastic Agents
/ therapeutic use
Aspirin
/ therapeutic use
Endometrial Neoplasms
/ prevention & control
Female
Humans
Neoplasm Recurrence, Local
/ prevention & control
Ovarian Neoplasms
/ prevention & control
Uterine Cervical Neoplasms
/ prevention & control
aspirin
cervical cancer
endometrial cancer
ovarian cancer
Journal
Women's health (London, England)
ISSN: 1745-5065
Titre abrégé: Womens Health (Lond)
Pays: United States
ID NLM: 101271249
Informations de publication
Date de publication:
Historique:
entrez:
6
10
2020
pubmed:
7
10
2020
medline:
23
7
2021
Statut:
ppublish
Résumé
Drug repurposing is the application of an existing licenced drug for a new indication and potentially provides a faster and cheaper approach to developing new anti-cancer agents. Gynaecological cancers contribute significantly to the global cancer burden, highlighting the need for low cost, widely accessible therapies. A large body of evidence supports the role of aspirin as an anti-cancer agent, and a number of randomized trials are currently underway aiming to assess the potential benefit of aspirin in the treatment of cancer. This review summarizes the evidence underpinning aspirin use for the prevention of the development and recurrence of gynaecological cancers (ovarian, endometrial and cervical) and potential mechanisms of action.
Identifiants
pubmed: 33019903
doi: 10.1177/1745506520961710
pmc: PMC7543116
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Antineoplastic Agents
0
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1745506520961710Subventions
Organisme : Department of Health
ID : 12/01/38
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12023/28
Pays : United Kingdom
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