Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study.
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
14
07
2020
accepted:
16
09
2020
pubmed:
7
10
2020
medline:
15
5
2021
entrez:
6
10
2020
Statut:
ppublish
Résumé
Postrandomization biases may influence the estimate of efficacy of supplemental vitamin D in diabetes prevention trials. In the Vitamin D and Type 2 Diabetes (D2d) study, repeated measures of serum 25-hydroxyvitamin D [25(OH)D] level provided an opportunity to test whether intratrial vitamin D exposure affected diabetes risk and whether the effect was modified by trial assignment (vitamin D vs. placebo). The D2d study compared the effect of daily supplementation with 100 μg (4,000 units) of vitamin D There was an interaction of trial assignment with intratrial 25(OH)D level in predicting diabetes risk (interaction Daily vitamin D supplementation to maintain a serum 25(OH)D level ≥100 nmol/L is a promising approach to reducing the risk of diabetes in adults with prediabetes.
Identifiants
pubmed: 33020052
pii: dc20-1765
doi: 10.2337/dc20-1765
pmc: PMC7770274
doi:
Substances chimiques
Vitamins
0
Vitamin D
1406-16-2
Types de publication
Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2916-2922Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK098245
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 by the American Diabetes Association.
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