The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance.
Glioblastoma
SRC tyrosine kinase
hypoxia
invasion
radioresistance
targeted therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
04 Oct 2020
04 Oct 2020
Historique:
received:
03
09
2020
revised:
28
09
2020
accepted:
30
09
2020
entrez:
6
10
2020
pubmed:
7
10
2020
medline:
7
10
2020
Statut:
epublish
Résumé
Advances in functional imaging are supporting neurosurgery and radiotherapy for glioblastoma, which still remains the most aggressive brain tumor with poor prognosis. The typical infiltration pattern of glioblastoma, which impedes a complete surgical resection, is coupled with a high rate of invasiveness and radioresistance, thus further limiting efficient therapy, leading to inevitable and fatal recurrences. Hypoxia is of crucial importance in gliomagenesis and, besides reducing radiotherapy efficacy, also induces cellular and molecular mediators that foster proliferation and invasion. In this review, we aimed at analyzing the biological mechanism of glioblastoma invasiveness and radioresistance in hypoxic niches of glioblastoma. We also discussed the link between hypoxia and radiation-induced radioresistance with activation of SRC proto-oncogene non-receptor tyrosine kinase, prospecting potential strategies to overcome the current limitation in glioblastoma treatment.
Identifiants
pubmed: 33020459
pii: cancers12102860
doi: 10.3390/cancers12102860
pmc: PMC7599682
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : PhD programme in Biotechnology
ID : Biometec
Organisme : PON AIM R&I 2014-2020
ID : E66C18001240007
Organisme : International PhD programme in Neuroscience
ID : PO FSE 2014-2020
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca - PRIN 2017
ID : 2017XKWWK9_004
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