Enhanced asthma-related fibroblast to myofibroblast transition is the result of profibrotic TGF-β/Smad2/3 pathway intensification and antifibrotic TGF-β/Smad1/5/(8)9 pathway impairment.
Adult
Airway Remodeling
/ physiology
Asthma
/ metabolism
Bronchi
/ metabolism
Case-Control Studies
Cells, Cultured
Female
Fibroblasts
/ metabolism
Humans
Male
Middle Aged
Myofibroblasts
/ metabolism
Signal Transduction
/ physiology
Smad Proteins, Receptor-Regulated
/ metabolism
Transforming Growth Factor beta
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 10 2020
05 10 2020
Historique:
received:
17
12
2019
accepted:
09
07
2020
entrez:
6
10
2020
pubmed:
7
10
2020
medline:
5
1
2021
Statut:
epublish
Résumé
Airway remodelling with subepithelial fibrosis, which abolishes the physiological functions of the bronchial wall, is a major issue in bronchial asthma. Human bronchial fibroblasts (HBFs) derived from patients diagnosed with asthma display in vitro predestination towards TGF-β
Identifiants
pubmed: 33020537
doi: 10.1038/s41598-020-73473-7
pii: 10.1038/s41598-020-73473-7
pmc: PMC7536388
doi:
Substances chimiques
Smad Proteins, Receptor-Regulated
0
Transforming Growth Factor beta
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16492Références
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