Stealth and Bright Monomolecular Fluorescent Organic Nanoparticles Based on Folded Amphiphilic Polymer.
aggregation-caused quenching
amphiphilic polymer
fluorescence imaging
fluorescent dyes
fluorescent nanoparticles
intracellular distribution
single-chain polymer folding
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
27 10 2020
27 10 2020
Historique:
pubmed:
7
10
2020
medline:
7
10
2020
entrez:
6
10
2020
Statut:
ppublish
Résumé
Fluorescent nanoparticles (NPs), owing to their superior brightness, are an attractive alternative to organic dyes. However, their cellular applications remain limited because of their large size, poor homogeneity, and nonspecific interactions in biological media. Herein, we propose a concept of monomolecular fluorescent organic nanoparticles of high brightness and very small size (10-14 nm) built of a single amphiphilic polymer bearing specially designed fluorescent dyes. We found that high PEGylation of poly(maleic anhydride-
Identifiants
pubmed: 33022173
doi: 10.1021/acsnano.0c06348
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM