The Immune Microenvironment in Pancreatic Cancer.
T-cells
cancer-associated fibroblasts
immunotherapy
macrophages
natural killer cells
neutrophils
pancreatic cancer
tumor stroma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Oct 2020
03 Oct 2020
Historique:
received:
08
09
2020
revised:
28
09
2020
accepted:
29
09
2020
entrez:
7
10
2020
pubmed:
8
10
2020
medline:
24
2
2021
Statut:
epublish
Résumé
The biology of solid tumors is strongly determined by the interactions of cancer cells with their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) represents a paradigmatic example for the multitude of possible tumor-stroma interactions. PDAC has proven particularly refractory to novel immunotherapies, which is a fact that is mediated by a unique assemblage of various immune cells creating a strongly immunosuppressive environment in which this cancer type thrives. In this review, we outline currently available knowledge on the cross-talk between tumor cells and the cellular immune microenvironment, highlighting the physiological and pathological cellular interactions, as well as the resulting therapeutic approaches derived thereof. Hopefully a better understanding of the complex tumor-stroma interactions will one day lead to a significant advancement in patient care.
Identifiants
pubmed: 33022971
pii: ijms21197307
doi: 10.3390/ijms21197307
pmc: PMC7583843
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : KFO325
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