Effect of Maternal Docosahexaenoic Acid (DHA) Supplementation on Offspring Neurodevelopment at 12 Months in India: A Randomized Controlled Trial.
India
docosahexaenoic acid (DHA)
lactation
maternal supplementation
neurodevelopment
pregnancy
randomized controlled trial (RCT)
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
03 Oct 2020
03 Oct 2020
Historique:
received:
14
08
2020
revised:
22
09
2020
accepted:
23
09
2020
entrez:
7
10
2020
pubmed:
8
10
2020
medline:
15
4
2021
Statut:
epublish
Résumé
Intake of dietary docosahexaenoic acid (DHA 22:6n-3) is very low among Indian pregnant women. Maternal supplementation during pregnancy and lactation may benefit offspring neurodevelopment. We conducted a double-blind, randomized, placebo-controlled trial to test the effectiveness of supplementing pregnant Indian women (singleton gestation) from ≤20 weeks through 6 months postpartum with 400 mg/d algal DHA compared to placebo on neurodevelopment of their offspring at 12 months. Of 3379 women screened, 1131 were found eligible; 957 were randomized. The primary outcome was infant neurodevelopment at 12 months, assessed using the Development Assessment Scale for Indian Infants (DASII). Both groups were well balanced on sociodemographic variables at baseline. More than 72% of women took >90% of their assigned treatment. Twenty-five serious adverse events (SAEs), none related to the intervention, (DHA group = 16; placebo = 9) were noted. Of 902 live births, 878 were followed up to 12 months; the DASII was administered to 863 infants. At 12 months, the mean development quotient (DQ) scores in the DHA and placebo groups were not statistically significant (96.6 ± 12.2 vs. 97.1 ± 13.0,
Identifiants
pubmed: 33023067
pii: nu12103041
doi: 10.3390/nu12103041
pmc: PMC7600740
pii:
doi:
Substances chimiques
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Wellcome Trust DBT India Alliance
ID : IA/CPHE/14/1/501498
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