The Effects of Immune System Modulation on Prion Disease Susceptibility and Pathogenesis.
aging
co-infection
immune system
inflammation
prions and prion disease
susceptibility
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Oct 2020
02 Oct 2020
Historique:
received:
09
09
2020
revised:
25
09
2020
accepted:
29
09
2020
entrez:
7
10
2020
pubmed:
8
10
2020
medline:
27
2
2021
Statut:
epublish
Résumé
Prion diseases are a unique group of infectious chronic neurodegenerative disorders to which there are no cures. Although prion infections do not stimulate adaptive immune responses in infected individuals, the actions of certain immune cell populations can have a significant impact on disease pathogenesis. After infection, the targeting of peripherally-acquired prions to specific immune cells in the secondary lymphoid organs (SLO), such as the lymph nodes and spleen, is essential for the efficient transmission of disease to the brain. Once the prions reach the brain, interactions with other immune cell populations can provide either host protection or accelerate the neurodegeneration. In this review, we provide a detailed account of how factors such as inflammation, ageing and pathogen co-infection can affect prion disease pathogenesis and susceptibility. For example, we discuss how changes to the abundance, function and activation status of specific immune cell populations can affect the transmission of prion diseases by peripheral routes. We also describe how the effects of systemic inflammation on certain glial cell subsets in the brains of infected individuals can accelerate the neurodegeneration. A detailed understanding of the factors that affect prion disease transmission and pathogenesis is essential for the development of novel intervention strategies.
Identifiants
pubmed: 33023255
pii: ijms21197299
doi: 10.3390/ijms21197299
pmc: PMC7582561
pii:
doi:
Substances chimiques
Prions
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/20002174
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/30002276
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S005471/1
Pays : United Kingdom
Références
Handb Clin Neurol. 2018;153:85-107
pubmed: 29887157
Intervirology. 1986;25(2):103-10
pubmed: 3013796
Neuron. 2017 May 17;94(4):759-773.e8
pubmed: 28521131
Immunology. 2013 Mar;138(3):246-57
pubmed: 23121447
Trends Immunol. 2014 Mar;35(3):105-13
pubmed: 24315719
J Gen Virol. 2014 Jan;95(Pt 1):231-243
pubmed: 24123519
Brain Behav Immun. 2020 Oct;89:601-603
pubmed: 32681865
J Immunol. 2003 Jun 15;170(12):6040-7
pubmed: 12794132
J Immunol. 2007 Nov 1;179(9):6144-52
pubmed: 17947689
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):E440-9
pubmed: 21788491
Nature. 1997 Oct 2;389(6650):448-50, 526
pubmed: 9333232
J Virol. 2015 Sep;89(18):9532-47
pubmed: 26157121
Neuropathol Appl Neurobiol. 2002 Apr;28(2):107-19
pubmed: 11972797
J Exp Med. 2016 May 30;213(6):1047-59
pubmed: 27185853
J Gen Virol. 1999 Oct;80 ( Pt 10):2757-2764
pubmed: 10573172
J Virol. 2002 May;76(9):4357-63
pubmed: 11932402
Trends Immunol. 2020 Sep;41(9):820-835
pubmed: 32819809
Nature. 1970 May 2;226(5244):462-3
pubmed: 4985820
J Comp Pathol. 1969 Jan;79(1):15-22
pubmed: 4975615
Neurobiol Aging. 2011 Nov;32(11):2006-15
pubmed: 20045218
J Immunol. 1973 Nov;111(5):1407-10
pubmed: 4200779
Acta Neuropathol Commun. 2019 May 22;7(1):83
pubmed: 31118110
J Immunol. 1998 Aug 1;161(3):1313-9
pubmed: 9686593
Science. 1982 Dec 24;218(4579):1309-11
pubmed: 6815801
Neurobiol Aging. 2015 May;36(5):1994-2003
pubmed: 25816748
Am J Pathol. 2011 Sep;179(3):1301-9
pubmed: 21763679
J Mol Biol. 2000 Jul 28;300(5):1309-22
pubmed: 10903871
mSphere. 2017 Nov 22;2(6):
pubmed: 29202042
J Clin Invest. 1998 Feb 15;101(4):890-8
pubmed: 9466984
J Infect Dis. 1967 Feb;117(1):15-22
pubmed: 4961240
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
Nat Med. 1999 Nov;5(11):1308-12
pubmed: 10545999
Vet Res. 2012 Dec 18;43:87
pubmed: 23249298
Nat Commun. 2018 Mar 28;9(1):1272
pubmed: 29593242
Nature. 2012 May 27;486(7403):410-4
pubmed: 22722203
J Pathol. 2000 Mar;190(4):495-502
pubmed: 10700001
Prion. 2012 Sep-Oct;6(4):322-33
pubmed: 22895090
PLoS One. 2009 Sep 25;4(9):e7160
pubmed: 19779609
Immunology. 2017 Jul;151(3):349-362
pubmed: 28369800
EMBO J. 1991 Jul;10(7):1661-9
pubmed: 2050106
Neurotherapeutics. 2020 Oct;17(4):1850-1860
pubmed: 32483654
PLoS Pathog. 2020 Jun 29;16(6):e1008653
pubmed: 32598380
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Front Cell Neurosci. 2019 Sep 10;13:411
pubmed: 31551718
Nature. 2020 Feb;578(7796):593-599
pubmed: 32051591
Sci Rep. 2019 Apr 30;9(1):6674
pubmed: 31040320
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23336-23338
pubmed: 32900927
Vet Res. 2009 Nov-Dec;40(6):65
pubmed: 19686637
PLoS Pathog. 2016 Jan 28;12(1):e1005401
pubmed: 26821311
Nature. 2013 Sep 5;501(7465):102-6
pubmed: 23903654
J Neurosci. 2005 Oct 5;25(40):9275-84
pubmed: 16207887
PLoS Pathog. 2016 Dec 14;12(12):e1006075
pubmed: 27973593
Cell. 2012 Jul 6;150(1):194-206
pubmed: 22770220
Glia. 2019 Jul;67(7):1254-1276
pubmed: 30680794
Glia. 2014 Mar;62(3):339-55
pubmed: 24588027
J Virol. 2007 Sep;81(18):9942-9
pubmed: 17626090
Lancet. 2003 Feb 8;361(9356):487-9
pubmed: 12583949
Immunity. 2004 Jun;20(6):769-83
pubmed: 15189741
Nature. 2012 May 06;485(7399):507-11
pubmed: 22622579
Mucosal Immunol. 2015 May;8(3):650-60
pubmed: 25336168
Cell. 2020 May 14;181(4):784-799.e19
pubmed: 32413299
J Neurovirol. 2004 Feb;10(1):29-40
pubmed: 14982726
Immunol Lett. 2007 Mar 15;109(1):64-71
pubmed: 17292972
PLoS Pathog. 2020 Jul 23;16(7):e1008283
pubmed: 32702070
J Cereb Blood Flow Metab. 2003 Oct;23(10):1174-82
pubmed: 14526228
Intervirology. 1982;17(4):201-7
pubmed: 6813286
J Neuroimmunol. 2006 Jun;175(1-2):19-30
pubmed: 16631260
Cell Rep. 2017 Jan 10;18(2):391-405
pubmed: 28076784
Science. 2012 Jan 27;335(6067):472-5
pubmed: 22282814
Nature. 1974 Jun 28;249(460):855-6
pubmed: 4209742
J Comp Pathol. 1978 Oct;88(4):563-73
pubmed: 101558
J Virol. 2006 Jan;80(1):474-82
pubmed: 16352571
iScience. 2020 Jun 26;23(6):101147
pubmed: 32454449
J Virol. 1991 Nov;65(11):6292-5
pubmed: 1681118
Nature. 2003 Oct 30;425(6961):957-62
pubmed: 14562059
J Immunol. 2012 Aug 15;189(4):1540-4
pubmed: 22772447
PLoS One. 2008 Mar 26;3(3):e1888
pubmed: 18365024
Nature. 2003 Mar 6;422(6927):80-3
pubmed: 12621436
Vet Rec. 1966 May 7;78(19):647-9
pubmed: 5948839
J Leukoc Biol. 2012 May;91(5):817-28
pubmed: 22389312
Science. 2000 May 19;288(5469):1257-9
pubmed: 10818004
Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C498-507
pubmed: 27413168
Nat Med. 2001 Apr;7(4):485-7
pubmed: 11283677
Mol Neurobiol. 1994 Apr-Jun;8(2-3):121-7
pubmed: 7999308
Mucosal Immunol. 2017 Nov;10(6):1412-1430
pubmed: 28378808
Int J Pharm. 2005 Jul 25;298(2):293-304
pubmed: 15964722
Brain Pathol. 2017 Sep;27(5):590-602
pubmed: 27558169
Brain Sci. 2018 Dec 19;8(12):
pubmed: 30572619
Neuron. 2007 Aug 2;55(3):353-64
pubmed: 17678850
Brain Behav Immun. 2017 Jan;59:233-244
pubmed: 27633985
Mol Brain. 2020 May 7;13(1):71
pubmed: 32381108
Lancet Neurol. 2006 May;5(5):393-8
pubmed: 16632309
Brain Behav Immun. 2010 Aug;24(6):996-1007
pubmed: 20399848
Nature. 1997 Dec 18-25;390(6661):687-90
pubmed: 9414161
Cell Host Microbe. 2020 Aug 12;28(2):201-222
pubmed: 32791113
Neurology. 2020 Oct 6;95(14):e2028-e2037
pubmed: 32098855
Science. 2001 Oct 5;294(5540):178-82
pubmed: 11546838
J Neurosci. 2015 Jun 3;35(22):8411-22
pubmed: 26041910
Neuron. 2020 Mar 4;105(5):855-866.e5
pubmed: 31924446
Cell Rep. 2020 Jun 23;31(12):107776
pubmed: 32579912
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3987-92
pubmed: 10097150
Adv Exp Med Biol. 1981;134:359-63
pubmed: 7194567
PLoS Pathog. 2008 Dec;4(12):e1000238
pubmed: 19079578
EMBO Mol Med. 2020 Sep 7;12(9):e12739
pubmed: 32776637
Neurodegeneration. 1994 Dec;3(4):331-40
pubmed: 7842304
Neuroscience. 2002;112(1):7-11
pubmed: 12044467
J Virol. 2018 Jul 17;92(15):
pubmed: 29769333
J Exp Med. 2010 Sep 27;207(10):2271-81
pubmed: 20837697
Lancet. 2002 Jul 20;360(9328):229-30
pubmed: 12133662
Arch Virol Suppl. 2000;(16):57-71
pubmed: 11214935
PLoS Pathog. 2011 Dec;7(12):e1002402
pubmed: 22144895
Nature. 2020 Sep;585(7823):102-106
pubmed: 32848245
Brain Res. 2015 Oct 14;1623:74-80
pubmed: 25795378
DNA Res. 2009 Aug;16(4):227-35
pubmed: 19675110
J Virol. 2017 Apr 28;91(10):
pubmed: 28275192
PLoS One. 2007 Sep 12;2(9):e859
pubmed: 17848990
J Gen Virol. 2008 Jun;89(Pt 6):1545-1550
pubmed: 18474572
mBio. 2019 Aug 6;10(4):
pubmed: 31387911
J Immunol. 2017 Dec 1;199(11):3821-3827
pubmed: 29070671
Immunity. 2006 Jan;24(1):65-77
pubmed: 16413924
Cell. 2016 Jan 28;164(3):378-91
pubmed: 26777404
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10608-12
pubmed: 7902565
Brain. 2019 Apr 1;142(4):1035-1050
pubmed: 30753318
Nat Commun. 2019 Jul 19;10(1):3215
pubmed: 31324781
Am J Pathol. 2016 May;186(5):1166-79
pubmed: 26948422
Clin Anat. 2014 Sep;27(6):821-32
pubmed: 24740900
Oxid Med Cell Longev. 2016;2016:3974648
pubmed: 28003864
Neurosci Lett. 1989 Jul 17;102(1):1-6
pubmed: 2550852
Nature. 1997 Oct 2;389(6650):498-501
pubmed: 9333239
J Neurosci. 2013 Feb 6;33(6):2481-93
pubmed: 23392676
Nature. 2020 Aug;584(7821):430-436
pubmed: 32640463
Nat Neurosci. 2015 Jul;18(7):965-77
pubmed: 26030851
Biochem Biophys Rep. 2015 Nov 05;4:397-404
pubmed: 29124230
J Gen Virol. 1986 Mar;67 ( Pt 3):463-73
pubmed: 2419489
Brain Res Dev Brain Res. 1999 Nov 18;117(2):145-52
pubmed: 10567732
J Vet Diagn Invest. 2012 Sep;24(5):878-87
pubmed: 22914819
Mucosal Immunol. 2015 May;8(3):582-95
pubmed: 25249168
Nature. 2020 Jun;582(7810):89-94
pubmed: 32483373
J Immunol. 2009 Nov 1;183(9):5738-47
pubmed: 19828638
Mucosal Immunol. 2012 Mar;5(2):216-25
pubmed: 22294048
Virus Res. 1989 Mar;12(3):201-11
pubmed: 2499134
J Neuropathol Exp Neurol. 2001 Feb;60(2):173-82
pubmed: 11273005
Nat Med. 2001 Apr;7(4):488-92
pubmed: 11283678
Trends Immunol. 2020 Sep;41(9):758-770
pubmed: 32819810
Front Cell Infect Microbiol. 2020 Jul 07;10:297
pubmed: 32733812
Emerg Top Life Sci. 2020 Sep 8;4(2):169-173
pubmed: 32633322
J Immunol. 2012 Nov 1;189(9):4520-7
pubmed: 23002439
EMBO J. 1997 Oct 15;16(20):6057-65
pubmed: 9321385
Nat Rev Immunol. 2008 Oct;8(10):764-75
pubmed: 18825130
PLoS One. 2017 May 17;12(5):e0177876
pubmed: 28545141
J Virol. 2005 Apr;79(8):5174-84
pubmed: 15795301
Lancet. 1975 Jan 25;1(7900):198-200
pubmed: 47424
Crit Rev Immunol. 1997;17(2):179-224
pubmed: 9094452
Nat Rev Microbiol. 2006 Oct;4(10):765-75
pubmed: 16980938
Protein Pept Lett. 2009;16(3):247-55
pubmed: 19275737
Immunology. 2017 Jan;150(1):7-15
pubmed: 27392533
Science. 2012 Jun 8;336(6086):1325-9
pubmed: 22582016
Eur J Immunol. 1994 Dec;24(12):3113-8
pubmed: 7805740
Nat Med. 2000 Jul;6(7):719-20
pubmed: 10888894
Int J Mol Med. 2010 Dec;26(6):845-51
pubmed: 21042778
Neurobiol Aging. 2009 Dec;30(12):1924-35
pubmed: 18375019
Curr Opin Microbiol. 2013 Jun;16(3):246-54
pubmed: 23880135
EMBO Rep. 2003 Feb;4(2):195-9
pubmed: 12612611
Immunology. 2014 Sep;143(1):120-9
pubmed: 24684244
Neuroscience. 2005;133(2):413-21
pubmed: 15878645
J Virol. 2000 Apr;74(7):3338-44
pubmed: 10708451
Nat Rev Immunol. 2014 Jul;14(7):495-504
pubmed: 24948364
Science. 2012 Jun 8;336(6086):1268-73
pubmed: 22674334
J Leukoc Biol. 2020 Feb;107(2):205-219
pubmed: 31330095
Cell. 2020 Jan 9;180(1):33-49.e22
pubmed: 31813624
Pathogens. 2017 Nov 24;6(4):
pubmed: 29186791
Trends Immunol. 2011 Dec;32(12):574-81
pubmed: 21940216
J Gen Virol. 2017 Jul;98(7):1943-1952
pubmed: 28708055
Vaccine. 2015 Jan 29;33(5):726-33
pubmed: 25539804
Nature. 1971 Oct 1;233(5318):336
pubmed: 4940428
PLoS Pathog. 2011 Dec;7(12):e1002449
pubmed: 22216002
Mucosal Immunol. 2013 Jul;6(4):666-77
pubmed: 23695511
J Virol. 2007 May;81(9):4877-80
pubmed: 17301133
Biol Psychiatry. 2009 Feb 15;65(4):304-12
pubmed: 18801476
APMIS. 2002 Jan;110(1):23-32
pubmed: 12064252
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
J Endocrinol. 2017 Jun;233(3):369-379
pubmed: 28438776
J Leukoc Biol. 1986 Jun;39(6):617-28
pubmed: 3011933
Nature. 2016 Aug 25;536(7617):464-8
pubmed: 27501152
J Virol. 2001 Oct;75(19):9320-7
pubmed: 11533195
Nat Med. 1998 Dec;4(12):1429-33
pubmed: 9846583
J Virol. 2008 Sep;82(17):8933-6
pubmed: 18579603
Science. 2005 Oct 14;310(5746):324-6
pubmed: 16224026
Nat Immunol. 2012 Jun 24;13(8):753-60
pubmed: 22729249
Am J Pathol. 2003 Apr;162(4):1103-11
pubmed: 12651603
Biochemistry. 1991 Aug 6;30(31):7672-80
pubmed: 1678278
J Virol. 2018 Sep 12;92(19):
pubmed: 30021891
Immunology. 2017 Jun;151(2):239-247
pubmed: 28207940
Int J Mol Sci. 2020 May 02;21(9):
pubmed: 32370224
Intervirology. 1981;16(1):8-13
pubmed: 6799420
Acta Neuropathol. 2012 Jul;124(1):111-26
pubmed: 22271154
Nature. 2020 Aug;584(7821):463-469
pubmed: 32717743
Nature. 2020 Jan;577(7790):399-404
pubmed: 31915375
Brain Behav Immun. 2016 Jul;55:179-190
pubmed: 26541819
Nat Rev Neurosci. 2003 Feb;4(2):103-12
pubmed: 12563281
PLoS Biol. 2016 Nov 23;14(11):e1002579
pubmed: 27880767
Nature. 2018 Jul;559(7712):109-113
pubmed: 29950724
Nature. 2011 Feb 24;470(7335):540-2
pubmed: 21350487
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):919-24
pubmed: 11792852
Nat Rev Immunol. 2013 Dec;13(12):888-902
pubmed: 24189576
Biochimie. 2015 Apr;111:82-106
pubmed: 25656912
Neurology. 2009 Sep 8;73(10):768-74
pubmed: 19738171
BMC Infect Dis. 2006 Jan 11;6:5
pubmed: 16405727
PLoS Pathog. 2020 Aug 26;16(8):e1008823
pubmed: 32845931
Mucosal Immunol. 2013 Sep;6(5):1027-37
pubmed: 23360902
Immunobiology. 2011 Nov;216(11):1228-37
pubmed: 21885153
Immunology. 2005 Feb;114(2):225-34
pubmed: 15667567
Jpn J Vet Res. 2006 Feb;53(3-4):149-57
pubmed: 16544935
Nat Rev Microbiol. 2006 Mar;4(3):201-11
pubmed: 16462753
Sci Rep. 2020 Mar 12;10(1):4554
pubmed: 32165661
Mult Scler. 2018 Mar;24(3):290-300
pubmed: 28277099
Cell Host Microbe. 2012 Nov 15;12(5):645-56
pubmed: 23159054
J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2224-2230
pubmed: 32687551
Neuron. 2001 Jul 19;31(1):25-34
pubmed: 11498048
Sci Rep. 2018 Jul 27;8(1):11326
pubmed: 30054538
Nature. 2013 Dec 19;504(7480):394-400
pubmed: 24270812
J Exp Med. 1994 Jan 1;179(1):347-51
pubmed: 8270879
J Virol. 2012 Jan;86(1):25-35
pubmed: 22031932
Int Immunol. 2013 Dec;25(12):697-702
pubmed: 24038599
Cell. 2014 Jul 17;158(2):300-313
pubmed: 25036630
Nature. 1978 Mar 2;272(5648):54-5
pubmed: 564461
PLoS One. 2015 Feb 11;10(2):e0117208
pubmed: 25671600
Mucosal Immunol. 2016 Jul;9(4):907-16
pubmed: 26601902
Glia. 2014 Jul;62(7):1041-52
pubmed: 24648328
Vet Res. 2008 Jul-Aug;39(4):24
pubmed: 18258167
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14000-5
pubmed: 26512113
Prion. 2014;8(4):286-95
pubmed: 25495404
Nat Med. 2005 Nov;11(11):1137-8
pubmed: 16270061
J Infect Dis. 2009 Jan 15;199(2):243-52
pubmed: 19072552
Neuroscience. 1996 Sep;74(1):1-5
pubmed: 8843071
Science. 1982 Apr 9;216(4542):136-44
pubmed: 6801762
J Gen Virol. 2016 Aug;97(8):1725-1738
pubmed: 27193137
J Immunol. 2011 Jun 15;186(12):7215-24
pubmed: 21572034
J Immunol. 2009 Oct 15;183(8):5199-207
pubmed: 19786551
Int J Mol Sci. 2020 Jan 28;21(3):
pubmed: 32012886
J Virol. 2003 Mar;77(6):3799-808
pubmed: 12610154
J Virol. 2002 May;76(10):5131-9
pubmed: 11967328
Cell Rep. 2015 May 5;11(5):770-84
pubmed: 25921539
Nature. 2013 Dec 19;504(7480):446-50
pubmed: 24226770
J Virol. 2011 Jan;85(2):1136-9
pubmed: 21084475
Immunity. 2008 Dec 19;29(6):998-1008
pubmed: 19100703
Tohoku J Exp Med. 1985 Aug;146(4):483-4
pubmed: 4071543
Sci Rep. 2019 Oct 10;9(1):14656
pubmed: 31601984
Nature. 2001 Nov 15;414(6861):269-70
pubmed: 11713518
J Neurosci. 2006 Nov 8;26(45):11753-62
pubmed: 17093096
Immunol Rev. 2014 Jul;260(1):8-20
pubmed: 24942678
Nature. 2020 May;581(7809):459-464
pubmed: 32461653
Parasitol Res. 2004 Aug;93(6):493-8
pubmed: 15278438
J Immunol. 2007 Mar 15;178(6):3757-66
pubmed: 17339474
J Virol. 2003 Jun;77(12):6845-54
pubmed: 12768004
Gut. 2020 Jun;69(6):1154-1156
pubmed: 31201287
Expert Rev Vaccines. 2015 Jan;14(1):1-4
pubmed: 25266267
Sci Adv. 2020 Jun 26;6(26):eaba3239
pubmed: 32637606
Nat Med. 2004 Feb;10(2):187-92
pubmed: 14745443
Nature. 2020 Mar;579(7798):265-269
pubmed: 32015508
J Virol. 2015 Dec 30;90(6):3003-17
pubmed: 26719249
J Immunol. 2007 Dec 1;179(11):7758-66
pubmed: 18025222
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4034-7
pubmed: 11274428
J Virol. 2012 May;86(9):4947-55
pubmed: 22379081