Reduced mitochondrial translation prevents diet-induced metabolic dysfunction but not inflammation.

mTOR and insulin signaling pathways metabolic syndrome mitochondria obesity stress response

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
06 Oct 2020
Historique:
received: 14 07 2020
accepted: 21 07 2020
pubmed: 8 10 2020
medline: 8 10 2020
entrez: 7 10 2020
Statut: ppublish

Résumé

The contribution of dysregulated mitochondrial gene expression and consequent imbalance in biogenesis is not well understood in metabolic disorders such as insulin resistance and obesity. The ribosomal RNA maturation protein PTCD1 is essential for mitochondrial protein synthesis and its reduction causes adult-onset obesity and liver steatosis. We used haploinsufficient

Identifiants

DOI: 10.18632/aging.104010 PMID: 33024056 PMC: PMC7732297
pubmed: 33024056
pii: 104010
doi: 10.18632/aging.104010
pmc: PMC7732297
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

19677-19700

Auteurs

Kara L Perks (KL)

Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia, Australia.
School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Western Australia, Australia.

Nicola Ferreira (N)

Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia, Australia.

Judith A Ermer (JA)

Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia, Australia.

Danielle L Rudler (DL)

Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia, Australia.

Tara R Richman (TR)

Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia, Australia.

Giulia Rossetti (G)

Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia, Australia.

Vance B Matthews (VB)

School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia.

Natalie C Ward (NC)

Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Western Australia, Australia.
School of Public Health and Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.

Oliver Rackham (O)

Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia, Australia.
School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Western Australia, Australia.
Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia.

Aleksandra Filipovska (A)

Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia, Australia.
School of Molecular Sciences, The University of Western Australia, Crawley, Western Australia, Australia.

Classifications MeSH