The "Road" to Atrial Fibrillation: The Role of the Cardiac Autonomic Nervous System.

Atrial fibrillation Autonomic dysfunction Autonomic nervous system Obesity Risk factors

Journal

Journal of atrial fibrillation
ISSN: 1941-6911
Titre abrégé: J Atr Fibrillation
Pays: United States
ID NLM: 101514767

Informations de publication

Date de publication:
Historique:
received: 06 01 2020
revised: 16 02 2020
accepted: 18 03 2020
entrez: 7 10 2020
pubmed: 8 10 2020
medline: 8 10 2020
Statut: epublish

Résumé

At the population level, there is a parallel escalation in the healthcare burden of both, atrial fibrillation (AF) as well its risk factors. Compounding this relationship, AF is associated with escalating burden at an individual level, due its self-perpetuating and progressive nature. The mechanisms by which these risk factors interact to produce atrial remodelling and subsequent AF are unclear. This intersection is critical to the development of strategies to combat this disease at both the individual and population-level. It is well known that AF can manifest from disturbances in autonomic activity. At the population level, there is growing data to suggest a role of the autonomic nervous system in the future incidence of AF. Here, we provide an overview of the association of cardiac autonomic dysfunction with the incidence of AF, review the role of the autonomic nervous system (ANS) as an intermediary between risk factors and the development of AF and finally, we discuss the bidirectional relationship between AF and cardiac autonomic nervous system dysfunction; to determine whether this is implicated in the progression of AF.

Identifiants

pubmed: 33024501
doi: 10.4022/jafib.2400
pmc: PMC7533139
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2400

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Auteurs

Varun Malik (V)

Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

Ricardo Mishima (R)

Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

Adrian D Elliott (A)

Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

Dennis H Lau (D)

Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

Prashanthan Sanders (P)

Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

Classifications MeSH