Ceramide/Sphingomyelin Rheostat Regulated by Sphingomyelin Synthases and Chronic Diseases in Murine Models.
Ceramide/SM balance
Ceramides
Murine disease models
SMS
Sphingomyelins
Journal
Journal of lipid and atherosclerosis
ISSN: 2287-2892
Titre abrégé: J Lipid Atheroscler
Pays: Korea (South)
ID NLM: 101610890
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
09
06
2020
revised:
16
07
2020
accepted:
19
07
2020
entrez:
7
10
2020
pubmed:
8
10
2020
medline:
8
10
2020
Statut:
ppublish
Résumé
Ceramide and sphingomyelin (SM) are major components of the double membrane-bound sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes including apoptosis, necrosis, and autophagy-dependent cell death. Inversely, SM regulates opposite cellular processes such as proliferation and migration by changing receptor-mediated signal transduction in the lipid microdomain. SM is generated through a transfer of phosphocholine from phosphatidylcholine to ceramide by SM synthases (SMSs). Research during the past several decades has revealed that the ceramide/SM balance in cellular membranes regulated by SMSs is important to decide the cell fate, survival, and proliferation. In addition, recent experimental studies utilizing SMS knockout mice and murine disease models provide evidence that SMS-regulated ceramide/SM balance is involved in human diseases. Here, we review the basic structural and functional characteristics of SMSs and focus on their cellular functions through the regulation of ceramide/SM balance in membrane microdomains. In addition, we present the pathological or physiological implications of SMSs by analyzing their role in SMS-knockout mice and human disease models. This review finally presents evidence indicating that the regulation of ceramide/SM balance through SMS could be a therapeutic target for human disorders.
Identifiants
pubmed: 33024732
doi: 10.12997/jla.2020.9.3.380
pmc: PMC7521967
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
380-405Informations de copyright
Copyright © 2020 The Korean Society of Lipid and Atherosclerosis.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors have no conflicts of interest to declare.
Références
J Invest Dermatol. 1991 Apr;96(4):523-6
pubmed: 2007790
FASEB J. 2018 Aug;32(8):4270-4283
pubmed: 29533737
Int J Mol Med. 2018 Dec;42(6):3344-3354
pubmed: 30272329
Int J Cancer. 2006 Jan 1;118(1):230-42
pubmed: 16003725
J Lipid Res. 2013 Mar;54(3):794-805
pubmed: 23160178
J Pharmacol Exp Ther. 2004 Jun;309(3):1051-9
pubmed: 14960662
Cells. 2020 Mar 05;9(3):
pubmed: 32151027
Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):850-6
pubmed: 19286635
J Cell Sci. 2014 Jan 15;127(Pt 2):445-54
pubmed: 24259670
Cell Death Dis. 2018 Jun 27;9(7):728
pubmed: 29950610
Int J Oncol. 2020 Feb;56(2):439-447
pubmed: 31894265
Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2114-20
pubmed: 20814016
Cell Signal. 2008 Jun;20(6):1010-8
pubmed: 18191382
Am J Respir Cell Mol Biol. 2020 Mar;62(3):342-353
pubmed: 31517509
Biochem J. 2012 Feb 1;441(3):789-802
pubmed: 22248339
FASEB J. 2017 Sep;31(9):3816-3830
pubmed: 28522594
J Biol Chem. 2006 Oct 6;281(40):29421-5
pubmed: 16905542
Annu Rev Biophys. 2018 May 20;47:633-654
pubmed: 29618220
Environ Toxicol Pharmacol. 2015 Nov;40(3):975-82
pubmed: 26562048
J Biol Chem. 2007 Jun 15;282(24):17537-47
pubmed: 17449912
J Lipid Res. 2019 May;60(5):913-918
pubmed: 30846529
J Biol Chem. 2018 Nov 23;293(47):18328-18336
pubmed: 30305392
Anticancer Drugs. 2003 Feb;14(2):167-73
pubmed: 12569304
Mol Cell Biol. 2012 Aug;32(16):3242-52
pubmed: 22688512
Circ Res. 2009 Jul 31;105(3):295-303
pubmed: 19590047
FEBS Lett. 2010 May 3;584(9):1728-40
pubmed: 20178791
Behav Brain Res. 2017 Feb 15;319:25-30
pubmed: 27840247
Exp Mol Pathol. 2007 Feb;82(1):1-11
pubmed: 16624283
J Biol Chem. 2004 Apr 30;279(18):18688-93
pubmed: 14976195
Brain Res. 2004 Oct 8;1023(1):31-40
pubmed: 15364016
J Lipid Res. 2015 Mar;56(3):537-45
pubmed: 25605874
J Med Chem. 2018 Sep 27;61(18):8241-8254
pubmed: 30074791
J Lipid Res. 2009 Nov;50(11):2270-7
pubmed: 19454763
Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2834-45
pubmed: 25634657
Cancers (Basel). 2019 Jan 14;11(1):
pubmed: 30646599
Proteins. 2009 Jan;74(1):1-5
pubmed: 18831011
Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L430-40
pubmed: 21191108
EBioMedicine. 2019 Jul;45:578-587
pubmed: 31262710
J Biol Chem. 2011 Aug 12;286(32):28544-55
pubmed: 21669879
PLoS One. 2013 Apr 12;8(4):e61380
pubmed: 23593476
Annu Rev Biochem. 1998;67:27-48
pubmed: 9759481
J Biol Chem. 2000 May 12;275(19):14760-6
pubmed: 10799564
J Biol Chem. 2014 Oct 31;289(44):30842-56
pubmed: 25231990
PLoS One. 2020 Mar 5;15(3):e0228385
pubmed: 32134954
PLoS One. 2016 Mar 24;11(3):e0152191
pubmed: 27010944
Trends Immunol. 2005 Mar;26(3):136-40
pubmed: 15745855
J Biol Chem. 2017 Mar 24;292(12):5110-5122
pubmed: 28087695
J Exp Med. 2005 Jul 18;202(2):249-59
pubmed: 16009715
EMBO J. 2004 Jan 14;23(1):33-44
pubmed: 14685263
Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C15-23
pubmed: 27194473
Cancer Lett. 1998 Apr 10;126(1):75-81
pubmed: 9563651
Int Immunol. 2012 May;24(5):327-37
pubmed: 22345277
Nat Rev Mol Cell Biol. 2008 Feb;9(2):139-50
pubmed: 18216770
Arch Biochem Biophys. 2008 Oct 1;478(1):52-8
pubmed: 18682246
Sci Signal. 2009 Apr 14;2(66):pe23
pubmed: 19366992
Oncol Lett. 2018 Jan;15(1):483-488
pubmed: 29375716
Mol Cancer Ther. 2018 Jan;17(1):50-59
pubmed: 29079707
J Biol Chem. 2011 Aug 12;286(32):27855-62
pubmed: 21693702
J Cell Physiol. 2003 Aug;196(2):354-61
pubmed: 12811829
Biochim Biophys Acta. 2008 Oct;1781(10):610-7
pubmed: 18694848
FEMS Yeast Res. 2006 Aug;6(5):751-62
pubmed: 16879426
J Biol Chem. 2019 Jan 11;294(2):502-519
pubmed: 30420430
Exp Dermatol. 2018 Aug;27(8):827-832
pubmed: 29345004
Blood. 2013 Nov 7;122(19):3340-8
pubmed: 24002447
Lipids Health Dis. 2011 Jan 17;10:7
pubmed: 21235823
Int Immunol. 2008 Nov;20(11):1427-37
pubmed: 18820264
Biol Reprod. 2011 May;84(5):851-8
pubmed: 21209417
Endocrinology. 1988 Nov;123(5):2600-2
pubmed: 2844518
Mol Med. 2019 Dec 17;25(1):56
pubmed: 31847800
FASEB J. 2020 Mar;34(3):3838-3854
pubmed: 31970839
Biochem J. 2011 Nov 15;440(1):127-35
pubmed: 21793801
Cell Death Differ. 2014 Jun;21(6):864-75
pubmed: 24488099
PLoS One. 2016 Oct 27;11(10):e0164298
pubmed: 27788151
Cell Rep. 2015 Mar 10;10(9):1626-1638
pubmed: 25753426
Blood. 2002 Jan 15;99(2):641-8
pubmed: 11781249
J Cell Sci. 2018 Sep 20;131(18):
pubmed: 30237248
N Engl J Med. 2014 Jan 30;370(5):455-65
pubmed: 24476434
J Lipid Res. 2015 Apr;56(4):821-35
pubmed: 25667419
Biomed Res. 2019;40(5):189-196
pubmed: 31597904
Mol Psychiatry. 2018 Dec;23(12):2324-2346
pubmed: 30038230
J Biol Chem. 2012 Nov 16;287(47):39898-910
pubmed: 23035115
Lipids. 1987 Nov;22(11):842-6
pubmed: 3444375
J Am Heart Assoc. 2019 Nov 19;8(22):e012885
pubmed: 31718447
J Cell Physiol. 2006 Jan;206(1):189-95
pubmed: 16021626
Clin Cancer Res. 2003 Jan;9(1):415-23
pubmed: 12538495
Nature. 2003 Dec 18;426(6968):803-9
pubmed: 14685229
Biochem Biophys Res Commun. 2007 Jun 22;358(1):196-202
pubmed: 17467659
Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1577-84
pubmed: 22580896
Int J Mol Sci. 2012;13(7):8834-52
pubmed: 22942738
J Biol Chem. 2011 Oct 14;286(41):36053-62
pubmed: 21856749
Nutr Metab (Lond). 2011 Dec 14;8:89
pubmed: 22168400
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19569-74
pubmed: 22106271
Biochim Biophys Acta. 2012 Apr;1821(4):684-93
pubmed: 22306364
JCI Insight. 2019 Apr 4;4(7):
pubmed: 30779713
J Biol Chem. 1992 Jun 5;267(16):11144-8
pubmed: 1317856
Sci Rep. 2017 Jan 25;7:41290
pubmed: 28120887
Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1519-26
pubmed: 18566297
Cell Res. 2018 Jan;28(1):9-21
pubmed: 29076500
Int Immunol. 2019 Mar 28;31(4):211-223
pubmed: 30561621
Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9
pubmed: 11413487
J Cell Biol. 2009 Jun 15;185(6):1013-27
pubmed: 19506037
Exp Cell Res. 2004 Jan 15;292(2):385-92
pubmed: 14697345
Eur J Med Chem. 2019 Feb 1;163:864-882
pubmed: 30580239
Cancer Res. 2004 Feb 1;64(3):1000-7
pubmed: 14871831
Lipids. 1987 Nov;22(11):820-3
pubmed: 3444372
J Biol Chem. 2018 Nov 9;293(45):17505-17522
pubmed: 30242129
ACS Med Chem Lett. 2019 Jul 03;10(8):1154-1158
pubmed: 31413799
Neuroreport. 2016 Sep 7;27(13):967-73
pubmed: 27391427
Biochim Biophys Acta. 2014 May;1841(5):692-703
pubmed: 24355909
Nat Rev Mol Cell Biol. 2018 Mar;19(3):175-191
pubmed: 29165427
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8489-94
pubmed: 22586083
Science. 1998 May 15;280(5366):1082-6
pubmed: 9582122
Life Sci. 2012 Jun 6;90(21-22):867-73
pubmed: 22538014
J Biol Chem. 2006 Sep 1;281(35):25001-5
pubmed: 16793762
Proc Natl Acad Sci U S A. 1966 Feb;55(2):366-9
pubmed: 5220952
Oncogene. 2004 Apr 29;23(20):3650-8
pubmed: 15077187
J Physiol. 2012 Aug 15;590(16):4029-44
pubmed: 22641779
Annu Rev Immunol. 2003;21:71-105
pubmed: 12414721
J Radiat Res. 2006 Mar;47(1):19-25
pubmed: 16571915
Blood. 2004 Nov 15;104(10):3285-93
pubmed: 15271800
Science. 2004 Feb 13;303(5660):1010-4
pubmed: 14963330
J Biol Chem. 2020 Mar 6;295(10):2932-2947
pubmed: 31980461
Blood. 2009 Oct 22;114(17):3588-600
pubmed: 19700666
Mol Cell Biol. 2011 Oct;31(20):4205-18
pubmed: 21844222
Autophagy. 2016 May 3;12(5):833-49
pubmed: 27070082
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
J Invest Dermatol. 1991 Jun;96(6):845-51
pubmed: 2045673
Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1513-20
pubmed: 23640498
J Lipid Res. 2015 Aug;56(8):1594-605
pubmed: 26116739
Biochem Pharmacol. 2011 Aug 1;82(3):287-94
pubmed: 21554861
J Clin Invest. 1998 Feb 15;101(4):905-12
pubmed: 9466986
Mol Neurobiol. 2015;51(3):1530-41
pubmed: 25084761
J Neurosci Res. 2000 Aug 15;61(4):430-5
pubmed: 10931529
Biochem J. 2007 Jan 15;401(2):541-9
pubmed: 17049047
Sci Rep. 2016 Nov 28;6:37829
pubmed: 27892528
J Biol Chem. 1958 Dec;233(6):1315-22
pubmed: 13610834
J Biol Chem. 2011 Feb 4;286(5):3992-4002
pubmed: 21115496
Leuk Res. 2015 Sep;39(9):964-70
pubmed: 26189109
J Dermatol Sci. 2020 Jan;97(1):2-8
pubmed: 31866207
Mol Cells. 2015 Jun;38(6):482-95
pubmed: 25997737
Metabolites. 2014 Jan 27;4(1):98-114
pubmed: 24958389
Biochem Biophys Res Commun. 2017 Jan 8;482(2):202-207
pubmed: 27836537
Exp Cell Res. 2008 May 1;314(8):1860-8
pubmed: 18374917