The effect of levomepromazine on the healthy and injured developing mouse brain - An
CCK-8, Cell Counting Kit-8
CD-1 mouse
HT-22
IQR, interquartile range
LMP, levomepromazine
Levomepromazine
Methotrimeprazine
NICU, Neonatal Intensive Care Unit
NaCl, sodium chloride
Neonatal excitotoxic brain injury
PBS, phosphate-buffered saline
Phenothiazine
Px, postnatal day x
TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling
bw, body weight
i.c., intracranial
i.p., intraperitoneal
Journal
IBRO reports
ISSN: 2451-8301
Titre abrégé: IBRO Rep
Pays: England
ID NLM: 101691215
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
25
07
2020
accepted:
15
09
2020
entrez:
7
10
2020
pubmed:
8
10
2020
medline:
8
10
2020
Statut:
epublish
Résumé
Levomepromazine (LMP) is a phenothiazine neuroleptic drug with strong analgesic and sedative properties that is increasingly used off-label in pediatrics and is being discussed as an adjunct therapy in neonatal intensive care. Basic research points towards neuroprotective potential of phenothiazines, but LMP's effect on the developing brain is currently unknown. The aim of the present study was to assess LMP as a pharmacologic strategy in established neonatal
Identifiants
pubmed: 33024879
doi: 10.1016/j.ibror.2020.09.003
pii: S2451-8301(20)30041-8
pmc: PMC7527626
doi:
Types de publication
Journal Article
Langues
eng
Pagination
247-257Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
We declare no conflict of interest.
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