Toxicokinetics and distribution in female rats after chronic nonylphenol exposure.

Animals Dose-Response Relationship, Drug Female Metabolic Clearance Rate Models, Biological Phenols / pharmacokinetics Random Allocation Rats Rats, Sprague-Dawley Toxicokinetics
Nonylphenol chronic low-dose oral exposure toxicokinetics

Journal

Toxicology and industrial health
ISSN: 1477-0393
Titre abrégé: Toxicol Ind Health
Pays: England
ID NLM: 8602702

Informations de publication

Date de publication:
Nov 2020
Historique:
pubmed: 8 10 2020
medline: 9 9 2021
entrez: 7 10 2020
Statut: ppublish

Résumé

Our previous studies have shown that continuous exposure to nonylphenol (NP) may cause female reproductive toxicity even at low doses. To better understand this toxic effect, the aim of this study was to investigate the basic characteristics of the disposal kinetics of NP under a chronic exposure scenario to simulate human exposure. Female rats were exposed to NP at three dose levels (50-, 500-, and 10,000 µg kg

Identifiants

DOI: 10.1177/0748233720958963 PMID: 33025838
pubmed: 33025838
doi: 10.1177/0748233720958963
doi:

Substances chimiques

Phenols 0
nonylphenol 79F6A2ILP5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

925-935

Auteurs

Haowei Fu (H)

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, 12579Southeast University, Nanjing, China.

Qiannan Di (Q)

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, 12579Southeast University, Nanjing, China.

Jinming Wang (J)

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, 12579Southeast University, Nanjing, China.

Qianqian Jiang (Q)

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, 12579Southeast University, Nanjing, China.

Qian Xu (Q)

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, 12579Southeast University, Nanjing, China.
ORCID: 0000-0003-2679-8295

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Toxicokinetics and distribution in female rats...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Toxicokinetics and distribution in female rats...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Taux de clairance métabolique › Toxicokinetics and distribution in female rats...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Toxicokinetics and distribution in female rats...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Toxicokinetics and distribution in female rats...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Répartition aléatoire › Toxicokinetics and distribution in female rats...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Toxicokinetics and distribution in female rats...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Toxicokinetics and distribution in female rats...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Toxicocinétique › Toxicokinetics and distribution in female rats...