Tapinarof to treat psoriasis.

Administration, Topical Clinical Trials as Topic Humans Psoriasis / drug therapy Receptors, Aryl Hydrocarbon / agonists Resorcinols / therapeutic use Stilbenes / therapeutic use
Antipsoriatics Aryl hydrocarbon receptor (AHR) agonists Dermatological disorders Psoriasis Tapinarof

Journal

Drugs of today (Barcelona, Spain : 1998)
ISSN: 1699-3993
Titre abrégé: Drugs Today (Barc)
Pays: Spain
ID NLM: 101160518

Informations de publication

Date de publication:
Aug 2020
Historique:
entrez: 7 10 2020
pubmed: 8 10 2020
medline: 9 10 2020
Statut: ppublish

Résumé

There is a need for new and effective topical treatment options for psoriasis. Recent phase I and II clinical trials have demonstrated efficacy of the novel nonsteroidal drug tapinarof to treat mild to moderate plaque psoriasis. Tapinarof is an aryl hydrocarbon receptor (AHR) agonist that induces antioxidant, immunomodulatory and epidermal differentiation regulation pathways. In this review, we examine the current preclinical and clinical studies with a focus on the mechanism of action, pharmacokinetics, safety and efficacy of tapinarof to treat psoriasis.

Identifiants

DOI: 10.1358/dot.2020.56.8.3168447 PMID: 33025947
pubmed: 33025947
pii: 3168447
doi: 10.1358/dot.2020.56.8.3168447
doi:

Substances chimiques

Receptors, Aryl Hydrocarbon 0
Resorcinols 0
Stilbenes 0
tapinarof 84HW7D0V04

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

515-530

Informations de copyright

Copyright 2020 Clarivate Analytics.

Auteurs

K Rodríguez Baisi (K)

Ponce Health Sciences University, Ponce, Puerto Rico.

M Tollefson (M)

Mayo Clinic, Department of Dermatology, Rochester, Minnesota, USA. Tollefson.Megha@mayo.edu.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie topique › Tapinarof to treat psoriasis.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Tapinarof to treat psoriasis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tapinarof to treat psoriasis.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › Tapinarof to treat psoriasis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs à hydrocarbure aromatique › Tapinarof to treat psoriasis.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Résorcinol › Tapinarof to treat psoriasis.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzylidéniques › Stilbènes › Tapinarof to treat psoriasis.