Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder.
bipolar disorder
education
intelligence
neuroimaging
relatives
schizophrenia
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
28
08
2020
received:
30
03
2020
accepted:
03
09
2020
pubmed:
8
10
2020
medline:
29
3
2022
entrez:
7
10
2020
Statut:
ppublish
Résumé
First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = -0.42, p = 3 × 10
Identifiants
pubmed: 33027543
doi: 10.1002/hbm.25206
pmc: PMC8675411
doi:
Types de publication
Journal Article
Meta-Analysis
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
414-430Subventions
Organisme : CSRD VA
ID : I01 CX000227
Pays : United States
Organisme : Swiss National Science Foundation
ID : 32003B_156914
Pays : Switzerland
Organisme : Medical Research Council
ID : G0901310
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0801418
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : NIH HHS
ID : R01MH121246
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH108150
Pays : United States
Organisme : VA
ID : I01CX000227
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : Wellcome Trust
ID : 091630
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : P41 EB027061
Pays : United States
Organisme : Wellcome Trust
ID : 064971
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH118695
Pays : United States
Organisme : NIH HHS
ID : 1S10OD017974-01
Pays : United States
Organisme : NIH HHS
ID : S10 OD017974
Pays : United States
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : NIH HHS
ID : U54EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111671
Pays : United States
Organisme : Department of Health
ID : NIHR200756
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : P30 NS076408
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH129742
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113619
Pays : United States
Organisme : NIH HHS
ID : P30 NS076408
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG058507
Pays : United States
Organisme : NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117601
Pays : United States
Organisme : NIA NIH HHS
ID : T32AG058507
Pays : United States
Organisme : NIH HHS
ID : R03 MH105808
Pays : United States
Organisme : Wellcome Trust
ID : 085475/B/08/Z
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH121246
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103703
Pays : United Kingdom
Organisme : CIHR
ID : 106469, 142255
Pays : Canada
Organisme : NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : Wellcome Trust
ID : 085475/Z/08/Z
Pays : United Kingdom
Organisme : NIH HHS
ID : R01 MH117601
Pays : United States
Organisme : NIH HHS
ID : R01 MH111671
Pays : United States
Organisme : NIMH NIH HHS
ID : R03 MH105808
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085667
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH052857
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH080912
Pays : United States
Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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