Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content.

Aged Aged, 80 and over Bile Acids and Salts / physiology Humans Lipid Metabolism / genetics Liver / pathology Metabolic Syndrome / physiopathology Middle Aged Obesity / physiopathology
bile acids diabetes enterohepatic circulation fatty liver genetics gut microbiome hyperlipidemia liver metabolic syndrome obesity

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
06 10 2020
Historique:
received: 25 06 2020
revised: 31 07 2020
accepted: 09 09 2020
entrez: 7 10 2020
pubmed: 8 10 2020
medline: 16 9 2021
Statut: ppublish

Résumé

Bile acids (BAs) are implicated in the etiology of obesity-related conditions such as non-alcoholic fatty liver disease. Differently structured BA species display variable signaling activities via farnesoid X receptor (FXR) and Takeda G protein-coupled BA receptor 1 (TGR5). This study profiles plasma and fecal BAs and plasma 7α-hydroxy-4-cholesten-3-one (C4) in 297 persons with obesity, identifies underlying genetic and microbial determinants, and establishes BA correlations with liver fat and plasma lipid parameters. We identify 27 genetic associations (p < 5 × 10

Identifiants

DOI: 10.1016/j.celrep.2020.108212 PMID: 33027657
pubmed: 33027657
pii: S2211-1247(20)31201-8
doi: 10.1016/j.celrep.2020.108212
pii:
doi:

Substances chimiques

Bile Acids and Salts 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108212

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Auteurs

Lianmin Chen (L)

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands.

Inge C L van den Munckhof (ICL)

Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.

Kiki Schraa (K)

Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.

Rob Ter Horst (R)

Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.

Martijn Koehorst (M)

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands.

Martijn van Faassen (M)

Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands.

Claude van der Ley (C)

Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands.

Marwah Doestzada (M)

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands.

Daria V Zhernakova (DV)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands; Laboratory of Genomic Diversity, Center for Computer Technologies, ITMO University, St. Petersburg 197101, Russia.

Alexander Kurilshikov (A)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands.

Vincent W Bloks (VW)

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands.

Albert K Groen (AK)

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands; Department of Vascular Medicine, University of Amsterdam, Amsterdam University Medical Center, Amsterdam 1012WX, the Netherlands.

Niels P Riksen (NP)

Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.

Joost H W Rutten (JHW)

Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.

Leo A B Joosten (LAB)

Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands; Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400000, Romania.

Cisca Wijmenga (C)

University of Groningen, Groningen 9712CP, the Netherlands.

Alexandra Zhernakova (A)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands.

Mihai G Netea (MG)

Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn 53113, Germany; Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova 200349, Romania.

Jingyuan Fu (J)

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands. Electronic address: j.fu@umcg.nl.

Folkert Kuipers (F)

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands. Electronic address: f.kuipers@umcg.nl.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Genetic and Microbial Associations to Plasma...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Genetic and Microbial Associations to Plasma...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Acides et sels biliaires › Genetic and Microbial Associations to Plasma...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic and Microbial Associations to Plasma...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Genetic and Microbial Associations to Plasma...
questionsmedicales.fr › Système digestif › Foie › Genetic and Microbial Associations to Plasma...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Syndrome métabolique X › Genetic and Microbial Associations to Plasma...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genetic and Microbial Associations to Plasma...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Genetic and Microbial Associations to Plasma...