Bone Morphogenic Proteins Are Immunoregulatory Cytokines Controlling FOXP3

Animals Bone Morphogenetic Proteins / immunology Cytokines / metabolism Forkhead Transcription Factors / immunology Humans Mice T-Lymphocytes, Regulatory / immunology
T cells Treg cells autoimmunity bone morphogenic proteins tissue homeostasis

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
06 10 2020
Historique:
received: 10 09 2019
revised: 28 07 2020
accepted: 10 09 2020
entrez: 7 10 2020
pubmed: 8 10 2020
medline: 16 9 2021
Statut: ppublish

Résumé

Bone morphogenic proteins (BMPs) are members of the transforming growth factor β (TGF-β) cytokine family promoting differentiation, homeostasis, and self-renewal of multiple tissues. We show that signaling through the bone morphogenic protein receptor 1α (BMPR1α) sustains expression of FOXP3 in T

Identifiants

DOI: 10.1016/j.celrep.2020.108219 PMID: 33027660 PMC: PMC7602518
pubmed: 33027660
pii: S2211-1247(20)31208-0
doi: 10.1016/j.celrep.2020.108219
pmc: PMC7602518
mid: NIHMS1635599
pii:
doi:

Substances chimiques

Bone Morphogenetic Proteins 0
Cytokines 0
FOXP3 protein, human 0
Forkhead Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

108219

Subventions

Organisme : NIAID NIH HHS
ID : R21 AI097600
Pays : United States

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors have declared no competing interests.

Auteurs

Lauren M Browning (LM)

Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA.

Caroline Miller (C)

Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA.

Michal Kuczma (M)

Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.

Maciej Pietrzak (M)

Department of Biomedical Informatics, Ohio State University, Columbus, OH 43210, USA.

Yu Jing (Y)

Center for Bioelectrics, Old Dominion University, Norfolk, VA 23529, USA.

Grzegorz Rempala (G)

College of Public Health, Ohio State University, Columbus, OH 43210, USA.

Pawel Muranski (P)

Columbia University Medical Center, New York, NY 10032, USA.

Leszek Ignatowicz (L)

Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.

Piotr Kraj (P)

Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA. Electronic address: pkraj@odu.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Bone Morphogenic Proteins Are Immunoregulatory...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Protéines morphogénétiques osseuses › Bone Morphogenic Proteins Are Immunoregulatory...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Bone Morphogenic Proteins Are Immunoregulatory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Bone Morphogenic Proteins Are Immunoregulatory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bone Morphogenic Proteins Are Immunoregulatory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Bone Morphogenic Proteins Are Immunoregulatory...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Bone Morphogenic Proteins Are Immunoregulatory...