Decoding the role of zebrafish neuroglia in CNS disease modeling.

Animals Central Nervous System Diseases Disease Models, Animal Humans Neuroglia Translational Research, Biomedical Zebrafish
CNS disorders Macroglia Microglia Neuroglia Rodents Zebrafish

Journal

Brain research bulletin
ISSN: 1873-2747
Titre abrégé: Brain Res Bull
Pays: United States
ID NLM: 7605818

Informations de publication

Date de publication:
01 2021
Historique:
received: 21 06 2020
revised: 14 09 2020
accepted: 25 09 2020
pubmed: 8 10 2020
medline: 4 1 2022
entrez: 7 10 2020
Statut: ppublish

Résumé

Neuroglia, including microglia and astrocytes, is a critical component of the central nervous system (CNS) that interacts with neurons to modulate brain activity, development, metabolism and signaling pathways. Thus, a better understanding of the role of neuroglia in the brain is critical. Complementing clinical and rodent data, the zebrafish (Danio rerio) is rapidly becoming an important model organism to probe the role of neuroglia in brain disorders. With high genetic and physiological similarity to humans and rodents, zebrafish possess some common (shared), as well as some specific molecular biomarkers and features of neuroglia development and functioning. Studying these common and zebrafish-specific aspects of neuroglia may generate important insights into key brain mechanisms, including neurodevelopmental, neurodegenerative, neuroregenerative and neurological processes. Here, we discuss the biology of neuroglia in humans, rodents and fish, its role in various CNS functions, and further directions of translational research into the role of neuroglia in CNS disorders using zebrafish models.

Identifiants

DOI: 10.1016/j.brainresbull.2020.09.020 PMID: 33027679
pubmed: 33027679
pii: S0361-9230(20)30642-0
doi: 10.1016/j.brainresbull.2020.09.020
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

44-53

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Konstantin N Zabegalov (KN)

School of Pharmacy, Southwest University, Chongqing, China; Ural Federal University, Ekaterinburg, Russia.

Dongmei Wang (D)

School of Pharmacy, Southwest University, Chongqing, China.

LongEn Yang (L)

School of Pharmacy, Southwest University, Chongqing, China.

Jingtao Wang (J)

School of Pharmacy, Southwest University, Chongqing, China.

Guojun Hu (G)

School of Pharmacy, Southwest University, Chongqing, China.

Nazar Serikuly (N)

School of Pharmacy, Southwest University, Chongqing, China.

Erik T Alpyshov (ET)

School of Pharmacy, Southwest University, Chongqing, China.

Sergey L Khatsko (SL)

Ural Federal University, Ekaterinburg, Russia.

Aleksander Zhdanov (A)

Ural Federal University, Ekaterinburg, Russia.

Konstantin A Demin (KA)

Institute of Experimental Medicine, Almazov National Medical Research Centre, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.

David S Galstyan (DS)

Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.

Andrey D Volgin (AD)

Scientific Research Institute of Neurosciences and Medicine, Novosibirsk, Russia; Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.

Murilo S de Abreu (MS)

Bioscience Institute, University of Passo Fundo, Passo Fundo, Brazil; Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia. Electronic address: abreu_murilo@hotmail.com.

Tatyana Strekalova (T)

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia; Division of Molecular Psychiatry, Centre of Mental Health, University of Würzburg, Würzburg, Germany.

Cai Song (C)

Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Zhanjiang, China; Marine Medicine Development Center, Shenzhen Institute, Guangdong Ocean University, Shenzhen, China.

Tamara G Amstislavskaya (TG)

Scientific Research Institute of Neurosciences and Medicine, Novosibirsk, Russia; Zelman Institute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, Russia.

Yury Sysoev (Y)

Laboratory of Neuroprosthetics, Institute of Translational Biomedicine, Petersburg State University, St. Petersburg, Russia; Department of Pharmacology and Clinical Pharmacology, St. Petersburg State Chemical Pharmaceutical University, St. Petersburg, Russia.

Pavel E Musienko (PE)

Laboratory of Neuroprosthetics, Institute of Translational Biomedicine, Petersburg State University, St. Petersburg, Russia; Institute of Phthisiopulmonology, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.

Allan V Kalueff (AV)

School of Pharmacy, Southwest University, Chongqing, China; Ural Federal University, Ekaterinburg, Russia. Electronic address: avkalueff@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Decoding the role of zebrafish neuroglia in...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Decoding the role of zebrafish neuroglia in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Decoding the role of zebrafish neuroglia in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Decoding the role of zebrafish neuroglia in...
questionsmedicales.fr › Cellules › Névroglie › Decoding the role of zebrafish neuroglia in...
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Recherche biomédicale › Recherche médicale translationnelle › Decoding the role of zebrafish neuroglia in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Decoding the role of zebrafish neuroglia in...