Integrative Analysis of Cell Crosstalk within Follicular Lymphoma Cell Niche: Towards a Definition of the FL Supportive Synapse.
B cells
Tfh
follicular lymphoma
mesenchymal stromal cells
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
05 Oct 2020
05 Oct 2020
Historique:
received:
01
09
2020
revised:
29
09
2020
accepted:
30
09
2020
entrez:
8
10
2020
pubmed:
9
10
2020
medline:
9
10
2020
Statut:
epublish
Résumé
Follicular lymphoma (FL), the most frequent indolent non-Hodgkin's B cell lymphoma, is considered as a prototypical centrocyte-derived lymphoma, dependent on a specific microenvironment mimicking the normal germinal center (GC). In agreement, several FL genetic alterations affect the crosstalk between malignant B cells and surrounding cells, including stromal cells and follicular helper T cells (Tfh). In our study, we sought to deconvolute this complex FL supportive synapse by comparing the transcriptomic profiles of GC B cells, Tfh, and stromal cells, isolated from normal versus FL tissues, in order to identify tumor-specific pathways. In particular, we highlighted a high expression of
Identifiants
pubmed: 33028033
pii: cancers12102865
doi: 10.3390/cancers12102865
pmc: PMC7599549
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Association pour la Recherche sur le Cancer
ID : PGA1 RF20170205386
Organisme : Infrastructure Program eCellFrance
ID : ANR-11-INSB-005
Organisme : Institut National Du Cancer
ID : PLBIO-18-060
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