Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients.

Acute Coronary Syndrome / blood Aged Angiography / methods Angiopoietin-2 / blood Biomarkers / blood Female Growth Differentiation Factor 15 / blood Humans Interleukin-1 Receptor-Like 1 Protein / blood Macula Lutea / blood supply Male Middle Aged Osteoprotegerin / blood Retinal Vessels / diagnostic imaging Risk Factors Tomography, Optical Coherence / methods Transforming Growth Factor beta1 / blood

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
07 10 2020
Historique:
received: 24 04 2020
accepted: 03 09 2020
entrez: 8 10 2020
pubmed: 9 10 2020
medline: 15 12 2020
Statut: epublish

Résumé

We aimed to compare retinal vascular density in Optical Coherence Tomography Angiography (OCT-A) between patients hospitalized for acute coronary syndrome (ACS) and control patients and to investigate correlation with angiogenesis biomarkers. Patients hospitalized for an acute coronary syndrome (ACS) in the Intensive Care Unit were included in the "high cardiovascular risk" group while patients without cardiovascular risk presenting in the Ophthalmology department were included as "control". Both groups had blood sampling and OCT-A imaging. Retina microvascularization density in the superficial capillary plexus was measured on 3 × 3 mm angiograms centered on the macula. Angiopoietin-2, TGF-β1, osteoprotegerin, GDF-15 and ST-2 were explored with ELISA or multiplex method. Overall, 62 eyes of ACS patients and 42 eyes of controls were included. ACS patients had significantly lower inner vessel length density than control patients (p = 0.004). A ROC curve found that an inner vessel length density threshold below 20.05 mm

Identifiants

DOI: 10.1038/s41598-020-73861-z PMID: 33028913 PMC: PMC7542456
pubmed: 33028913
doi: 10.1038/s41598-020-73861-z
pii: 10.1038/s41598-020-73861-z
pmc: PMC7542456
doi:

Substances chimiques

Angiopoietin-2 0
Biomarkers 0
Growth Differentiation Factor 15 0
IL1RL1 protein, human 0
Interleukin-1 Receptor-Like 1 Protein 0
Osteoprotegerin 0
TGFB1 protein, human 0
Transforming Growth Factor beta1 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

16718

Références

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Auteurs

Marc-Antoine Hannappe (MA)

Ophthalmology Department, University Hospital, 14 rue Paul Gaffarel, 21079, Dijon Cedex, France.
Laboratoire de Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (EA7460, PEC2), UFR Des Sciences de Santé, Bourgogne Franche-Comté University, Dijon, France.

Louis Arnould (L)

Ophthalmology Department, University Hospital, 14 rue Paul Gaffarel, 21079, Dijon Cedex, France. louis.arnould@chu-dijon.fr.
Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, 21000, Dijon, France. louis.arnould@chu-dijon.fr.
INSERM, CIC1432, Clinical Epidemiology Unit, Dijon, France. louis.arnould@chu-dijon.fr.
Dijon University Hospital, Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Dijon, France. louis.arnould@chu-dijon.fr.

Alexandre Méloux (A)

Laboratoire de Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (EA7460, PEC2), UFR Des Sciences de Santé, Bourgogne Franche-Comté University, Dijon, France.
Cardiology Department, University Hospital, Dijon, France.

Basile Mouhat (B)

Laboratoire de Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (EA7460, PEC2), UFR Des Sciences de Santé, Bourgogne Franche-Comté University, Dijon, France.
Cardiology Department, University Hospital, Dijon, France.

Florence Bichat (F)

Laboratoire de Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (EA7460, PEC2), UFR Des Sciences de Santé, Bourgogne Franche-Comté University, Dijon, France.
Cardiology Department, University Hospital, Dijon, France.

Marianne Zeller (M)

Laboratoire de Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (EA7460, PEC2), UFR Des Sciences de Santé, Bourgogne Franche-Comté University, Dijon, France.
Cardiology Department, University Hospital, Dijon, France.

Yves Cottin (Y)

Laboratoire de Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (EA7460, PEC2), UFR Des Sciences de Santé, Bourgogne Franche-Comté University, Dijon, France.
Cardiology Department, University Hospital, Dijon, France.

Christine Binquet (C)

INSERM, CIC1432, Clinical Epidemiology Unit, Dijon, France.
Dijon University Hospital, Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Dijon, France.

Catherine Vergely (C)

Laboratoire de Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (EA7460, PEC2), UFR Des Sciences de Santé, Bourgogne Franche-Comté University, Dijon, France.

Catherine Creuzot-Garcher (C)

Ophthalmology Department, University Hospital, 14 rue Paul Gaffarel, 21079, Dijon Cedex, France.
INSERM, CIC1432, Clinical Epidemiology Unit, Dijon, France.
Dijon University Hospital, Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Dijon, France.

Charles Guenancia (C)

Laboratoire de Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (EA7460, PEC2), UFR Des Sciences de Santé, Bourgogne Franche-Comté University, Dijon, France.
Cardiology Department, University Hospital, Dijon, France.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Syndrome coronarien aigu › Vascular density with optical coherence...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Vascular density with optical coherence...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic cardiovasculaire › Angiographie › Vascular density with optical coherence...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Angiopoïétines › Angiopoïétine-2 › Vascular density with optical coherence...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Vascular density with optical coherence...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteurs de croissance et de différenciation › Facteur-15 de croissance et de différenciation › Vascular density with optical coherence...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Vascular density with optical coherence...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-1 › Protéine-1 analogue au récepteur de l'interleukin-1 › Vascular density with optical coherence...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Macula › Vascular density with optical coherence...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Vascular density with optical coherence...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux facteurs de nécrose tumorale › Récepteurs leurres aux facteurs de nécrose tumorale › Ostéoprotégérine › Vascular density with optical coherence...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Vaisseaux rétiniens › Vascular density with optical coherence...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Vascular density with optical coherence...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Tomographie optique › Tomographie par cohérence optique › Vascular density with optical coherence...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Facteur de croissance transformant bêta-1 › Vascular density with optical coherence...