Evaluation of 1-Propanol Toxicity in B6C3F1 Mice via Repeated Inhalation over 28 and 90 Days.
Journal
Journal of toxicology
ISSN: 1687-8191
Titre abrégé: J Toxicol
Pays: Egypt
ID NLM: 101519097
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
08
2019
revised:
27
12
2019
accepted:
27
07
2020
entrez:
8
10
2020
pubmed:
9
10
2020
medline:
9
10
2020
Statut:
epublish
Résumé
We evaluated the toxicity of 1-propanol exposure following repeated inhalation over 28- and 90-day periods in male and female B6C3F1 mice to confirm the potential target organs and to determine the no-observable-adverse-effect levels (NOAELs). Five mice of each sex were exposed to 1-propanol at concentrations of 0, 100, 400, or 1600 ppm for 28 days and showed no consequent toxicity. Following this, ten mice of each sex were exposed at concentrations of 0, 500, 1600, or 5200 ppm for 90 days. We observed no effects on food consumption, body weight, organ weight, clinical signs, hematology and biochemistry parameters, or gross or histological features even at the maximum concentration. Therefore, the NOAEL of inhaled 1-propanol was defined as 5200 ppm (12.8 mg/L) for male and female mice under study conditions.
Identifiants
pubmed: 33029140
doi: 10.1155/2020/9172569
pmc: PMC7532428
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9172569Informations de copyright
Copyright © 2020 Eun-Sang Cho et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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