The Biology of the Intestinal Intracellular Parasite Cryptosporidium.
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
07 10 2020
07 10 2020
Historique:
received:
01
07
2020
revised:
17
08
2020
accepted:
09
09
2020
entrez:
8
10
2020
pubmed:
9
10
2020
medline:
25
5
2021
Statut:
ppublish
Résumé
Cryptosporidium emerged as a leading global cause of severe diarrheal disease in children. The parasite occupies a unique intracellular niche at the brush border of intestinal epithelial cells, where it undergoes a complex sexual life cycle. How this life cycle unfolds and how host and parasite interact remain largely to be discovered. A series of technical advances now offer genetic and immunological tools for mechanistic investigation of the parasite. Here we introduce the pathogen and disease and highlight important questions to tackle onward. We invite scientists to consider this versatile parasite model to probe the biology and immunology of the intestine.
Identifiants
pubmed: 33031769
pii: S1931-3128(20)30508-4
doi: 10.1016/j.chom.2020.09.007
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
509-515Subventions
Organisme : NIAID NIH HHS
ID : R01 AI127798
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI112427
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148249
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests B.S. is listed on a provisionary patent application by the University of Georgia for Cryptosporidium transfection filed in 2015.