Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals.
Aerosols
Animals
Binding Sites
Birds
/ virology
Ferrets
/ virology
Hemagglutinin Glycoproteins, Influenza Virus
/ chemistry
Humans
Influenza A Virus, H10N7 Subtype
Influenza A virus
/ metabolism
Influenza in Birds
/ virology
Mammals
Membrane Fusion
Models, Molecular
Orthomyxoviridae Infections
/ diagnosis
Polysaccharides
Sialic Acids
/ metabolism
A/H10N7
aerosol
glycan microarrays
hemagglutinin
influenza
receptor-binding
respiratory droplet
stability
transmission
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
07 10 2020
07 10 2020
Historique:
received:
28
11
2019
revised:
04
06
2020
accepted:
26
08
2020
entrez:
8
10
2020
pubmed:
9
10
2020
medline:
25
5
2021
Statut:
ppublish
Résumé
In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along North-European coastal waters, significantly impacting seal populations. Here, we examine the cross-species transmission and mammalian adaptation of this influenza A virus, revealing changes in the hemagglutinin surface protein that increase stability and receptor binding. The seal A/H10N7 virus was aerosol or respiratory droplet transmissible between ferrets. Compared with avian H10 hemagglutinin, seal H10 hemagglutinin showed stronger binding to the human-type sialic acid receptor, with preferential binding to α2,6-linked sialic acids on long extended branches. In X-ray structures, changes in the 220-loop of the receptor-binding pocket caused similar interactions with human receptor as seen for pandemic strains. Two substitutions made seal H10 hemagglutinin more stable than avian H10 hemagglutinin and similar to human hemagglutinin. Consequently, identification of avian-origin influenza viruses across mammals appears critical to detect influenza A viruses posing a major threat to humans and other mammals.
Identifiants
pubmed: 33031770
pii: S1931-3128(20)30466-2
doi: 10.1016/j.chom.2020.08.011
pmc: PMC7556738
mid: NIHMS1626951
pii:
doi:
Substances chimiques
Aerosols
0
Hemagglutinin Glycoproteins, Influenza Virus
0
Polysaccharides
0
Sialic Acids
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
602-613.e7Subventions
Organisme : Arthritis Research UK
ID : FC001078
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001143
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001143
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001078
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI114730
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400008C
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests Albert Osterhaus is CSO and co-founder Viroclinics Biosciences and CR2O as well as ad hoc consultant, invited speaker, and SAB member to pharmaceutical companies.
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