Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species.
Cell proliferation
Cell signaling
EndoG
Humanin
Mitochondria
Reactive oxygen species
Romo1
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
16
06
2020
revised:
29
08
2020
accepted:
18
09
2020
pubmed:
9
10
2020
medline:
22
6
2021
entrez:
8
10
2020
Statut:
ppublish
Résumé
The apoptotic nuclease EndoG is involved in mitochondrial DNA replication. Previous results suggested that, in addition to regulate cardiomyocyte hypertrophy, EndoG could be involved in cell proliferation. Here, by using in vivo and cell culture models, we investigated the role of EndoG in cell proliferation. Genetic deletion of Endog both in vivo and in cultured cells or Endog silencing in vitro induced a defect in rodent and human cell proliferation with a tendency of cells to accumulate in the G
Identifiants
pubmed: 33032073
pii: S2213-2317(20)30941-1
doi: 10.1016/j.redox.2020.101736
pmc: PMC7552104
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
Glycogen Synthase Kinase 3 beta
EC 2.7.11.1
Endodeoxyribonucleases
EC 3.1.-
endonuclease G
EC 3.1.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101736Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
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