Do components of adult height predict body composition and cardiometabolic risk in a young adult South Asian Indian population? Findings from a hospital-based cohort study in Pune, India: Pune Children's Study.
cardiac epidemiology
diabetes and endocrinology
epidemiology
preventive medicine
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
07 10 2020
07 10 2020
Historique:
entrez:
9
10
2020
pubmed:
10
10
2020
medline:
15
5
2021
Statut:
epublish
Résumé
We investigated whether the relationship between components of height and cardiovascular disease (CVD) risk may be explained by body composition. We also examined relationships between parental heights and offspring CVD risk. A cohort study using cross-sectional data. A secondary care hospital setting in Pune, India. We studied 357 young adults and their parents in the Pune Children's Study. Primary and secondary outcomes: we measured weight, total height, leg length, sitting height, plasma glucose, insulin and lipids, and blood pressure (BP). Total and regional lean and fat mass were measured by dual X-ray absorptiometry. Leg length was inversely related, and sitting height was directly related to BMI. Total height and leg length were directly related to lean mass, while sitting height was directly related to both lean and fat mass. Leg length was inversely related to systolic BP and 120 min glucose, independent of lean and fat mass. Sitting height was directly related to systolic BP and triglycerides; these relationships were attenuated on adjustment for lean and fat mass. When examined simultaneously, greater leg length was protective and greater sitting height was associated with a more detrimental CVD risk profile. Shorter adult leg length and greater sitting height are associated with a more adverse CVD risk factor profile. The mechanisms need further study, but our findings suggest a role for lean and fat mass.
Identifiants
pubmed: 33033015
pii: bmjopen-2020-036897
doi: 10.1136/bmjopen-2020-036897
pmc: PMC7542941
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e036897Subventions
Organisme : Medical Research Council
ID : MC_UU_12011/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400519
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 083460/Z/07/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J000094/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U147585821
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_A620_1016
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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