Impact of non-formulary drugs on pharmacological prescription in hospitalised patients.
drug formulary management
drug procurement
drug substitution (process)
drug substitution policy
health informatics
Journal
European journal of hospital pharmacy : science and practice
ISSN: 2047-9956
Titre abrégé: Eur J Hosp Pharm
Pays: England
ID NLM: 101578294
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
09
01
2020
revised:
26
08
2020
accepted:
15
09
2020
pubmed:
10
10
2020
medline:
2
4
2022
entrez:
9
10
2020
Statut:
ppublish
Résumé
The growing number of drugs on the market makes it necessary to adapt hospital formularies in order to ensure consistent drug coverage. The aim of this study was to evaluate the impact of the prescription of non-formulary drugs (NFD) on the therapeutic management of admitted patients. This retrospective observational study included NFD prescriptions in patients hospitalised in a tertiary university hospital during the period 2012-2015. NFD prescriptions are displayed on the computerised medical order as a pending alert to be reviewed by the clinical pharmacists, who make a notation to the clinical course that includes a recommendation for an available therapeutic alternative when available in the hospital formulary. The degree of acceptance of the recommendation by physicians is recorded. Approximately 0.5% of patients hospitalised during the study period were affected by an NFD prescription. A total of 52 (9.5%) NFD were of doubtful therapeutic efficacy, five (0.9%) were non-replaceable drugs and 490 (89.4%) were prescriptions for drugs with an alternative available in the hospital formulary. The acceptance rate for the recommended alternative was 34.9% in the evaluable NFD prescriptions. No correlation was observed between the number of NFD prescriptions or the number of NFD and the availability index (drugs included in the hospital formulary in relation to the total number of drugs marketed). The number of patients with a NFD prescription was very low. The lack of correlation between the number of NFD or NFD prescriptions and the availability index demonstrated that the hospital formulary covers practically all therapeutic needs.
Identifiants
pubmed: 33033109
pii: ejhpharm-2020-002204
doi: 10.1136/ejhpharm-2020-002204
pmc: PMC8640380
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e92-e96Informations de copyright
© European Association of Hospital Pharmacists 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Pharmacotherapy. 2002 Apr;22(4):500-12
pubmed: 11939685
Am J Health Syst Pharm. 2000 May 15;57(10):999-1000
pubmed: 10832505
Am J Health Syst Pharm. 2008 Jul 15;65(14):1368-84
pubmed: 18593684
Adv Ther. 2005 Jan-Feb;22(1):1-9
pubmed: 15943216
J Am Med Inform Assoc. 2016 Sep;23(5):924-33
pubmed: 27002076
Am J Health Syst Pharm. 2002 Mar 15;59(6):529-33
pubmed: 11908245
Rhinology. 1996 Mar;34(1):9-13
pubmed: 8739860
Am J Health Syst Pharm. 2016 Jan 1;73(1):e34-45
pubmed: 26683678
Pharmacotherapy. 2005 Nov;25(11):1666-80
pubmed: 16232030
Am J Health Syst Pharm. 2002 Feb 15;59(4):349-54
pubmed: 11885398
Am J Health Syst Pharm. 2000 May 1;57(9):882-6
pubmed: 10840529