Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
08 10 2020
08 10 2020
Historique:
received:
30
03
2020
accepted:
14
09
2020
revised:
09
09
2020
entrez:
9
10
2020
pubmed:
10
10
2020
medline:
22
6
2021
Statut:
epublish
Résumé
No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area and subcortical volume and tested classification performance using cross-validation. Classification performance for OCD vs. controls using the complete sample with different classifiers and cross-validation strategies was poor. When models were validated on data from other sites, model performance did not exceed chance-level. In contrast, fair classification performance was achieved when patients were grouped according to their medication status. These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.
Identifiants
pubmed: 33033241
doi: 10.1038/s41398-020-01013-y
pii: 10.1038/s41398-020-01013-y
pmc: PMC7598942
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
342Subventions
Organisme : NIMH NIH HHS
ID : R21 MH110865
Pays : United States
Organisme : Wellcome Trust
ID : 064846
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH115206
Pays : United States
Investigateurs
Nerisa Banaj
(N)
Nuria Bargalló
(N)
Marcelo C Batistuzzo
(MC)
Daniel Brandeis
(D)
Geraldo F Busatto
(GF)
Anna Calvo
(A)
Valentina Ciullo
(V)
Renate Drechsler
(R)
Madalena Esteves
(M)
Andrea Falini
(A)
Yu Fang
(Y)
Martijn Figee
(M)
Martine Fontaine
(M)
Margot Gueguen
(M)
Sayo Hamatani
(S)
Gregory L Hanna
(GL)
Bjarne Hansen
(B)
Keisuke Ikari
(K)
Luisa Lázaro
(L)
Ricardo Magalhães
(R)
Yasutaka Masuda
(Y)
Koji Matsumoto
(K)
Euripedes C Miguel
(EC)
Astrid Morer
(A)
Christopher Pittenger
(C)
Sara Poletti
(S)
Yuki Sakai
(Y)
Nuno Sousa
(N)
Jumpei Takahashi
(J)
Anders L Thorsen
(AL)
Aki Tsuchiyagaito
(A)
Daniela Vecchio
(D)
Dick J Veltman
(DJ)
Susanne Walitza
(S)
Anri Watanabe
(A)
Xiufeng Xu
(X)
Jian Xu
(J)
Kei Yamada
(K)
Tokiko Yoshida
(T)
Mojtaba Zarei
(M)
Qing Zhao
(Q)
Cong Zhou
(C)
Froukje E de Vries
(FE)
Stella J de Wit
(SJ)
Daan van Rooij
(D)
Guido A van Wingen
(GA)
Odile A van den Heuvel
(OA)
Ysbrand D van der Werf
(YD)
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