Spatial analysis of hepatobiliary abnormalities in a population at high-risk of cholangiocarcinoma in Thailand.
Adult
Age Factors
Animals
Bayes Theorem
Bile Duct Neoplasms
/ diagnostic imaging
Bile Ducts, Intrahepatic
/ diagnostic imaging
Cholangiocarcinoma
/ diagnostic imaging
Female
Humans
Male
Mass Screening
/ methods
Middle Aged
Opisthorchiasis
/ complications
Prevalence
Risk
Sex Factors
Spatial Analysis
Thailand
/ epidemiology
Ultrasonography
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 10 2020
08 10 2020
Historique:
received:
20
06
2020
accepted:
16
09
2020
entrez:
9
10
2020
pubmed:
10
10
2020
medline:
26
2
2021
Statut:
epublish
Résumé
Cholangiocarcinoma (CCA) is a serious health challenge with low survival prognosis. The liver fluke, Opisthorchis viverrini, plays a role in the aetiology of CCA, through hepatobiliary abnormalities: liver mass (LM), bile duct dilation, and periductal fibrosis (PDF). A population-based CCA screening program, the Cholangiocarcinoma Screening and Care Program, operates in Northeast Thailand. Hepatobiliary abnormalities were identified through ultrasonography. A multivariate zero-inflated, Poisson regression model measured associations between hepatobiliary abnormalities and covariates including age, sex, distance to water resource, and history of O. viverrini infection. Geographic distribution was described using Bayesian spatial analysis methods. Hepatobiliary abnormality prevalence was 38.7%; highest in males aged > 60 years (39.8%). PDF was most prevalent (20.1% of males). The Standardized Morbidity Ratio (SMR) for hepatobiliary abnormalities was highest in the lower and upper parts of the Northeast region. Hepatobiliary abnormalities specifically associated with CCA were also more common in males and those aged over 60 years and distributed along the Chi, Mun, and Songkram Rivers. Our findings demonstrated a high risk of hepatobiliary disorders in Northeast Thailand, likely associated with infection caused by O. viverrini. Screening for CCA and improvement of healthcare facilities to provide better treatment for CCA patients should be prioritized in these high-risk areas.
Identifiants
pubmed: 33033306
doi: 10.1038/s41598-020-73771-0
pii: 10.1038/s41598-020-73771-0
pmc: PMC7545164
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16855Références
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