Surgical treatment of gallbladder cancer: An eight-year experience in a single center.
Extrahepatic bile duct
Gallbladder cancer
Lymph node
Metastasis
Outcome
Prognosis
Surgery
Journal
World journal of hepatology
ISSN: 1948-5182
Titre abrégé: World J Hepatol
Pays: United States
ID NLM: 101532469
Informations de publication
Date de publication:
27 Sep 2020
27 Sep 2020
Historique:
received:
09
03
2020
revised:
10
07
2020
accepted:
18
07
2020
entrez:
9
10
2020
pubmed:
10
10
2020
medline:
10
10
2020
Statut:
ppublish
Résumé
Gallbladder cancer (GBC) is the most common biliary malignancy and has the worst prognosis, but aggressive surgeries [ To present our data together with a discussion of the therapeutic strategies for GBC. We retrospectively investigated nineteen GBC patients who underwent surgical treatment. Nearly all symptomatic patients had poor outcomes, while suspicious or incidental GBCs at early stages showed excellent outcomes without the need for two-stage surgery. Lymph nodes around the cystic duct were reliable sentinel nodes in suspicious/incidental GBCs. Intentional LN dissection and EHBD resection prevented metastases or recurrence in early-stage GBCs but not in advanced GBCs with metastatic LNs or invasion of the nerve plexus. All patients with positive surgical margins ( Outcomes for GBC patients remain unacceptable, and improved therapeutic strategies, including neoadjuvant chemotherapy, optimal surgery and adjuvant chemotherapy, should be considered for patients with advanced GBCs.
Sections du résumé
BACKGROUND
BACKGROUND
Gallbladder cancer (GBC) is the most common biliary malignancy and has the worst prognosis, but aggressive surgeries [
AIM
OBJECTIVE
To present our data together with a discussion of the therapeutic strategies for GBC.
METHODS
METHODS
We retrospectively investigated nineteen GBC patients who underwent surgical treatment.
RESULTS
RESULTS
Nearly all symptomatic patients had poor outcomes, while suspicious or incidental GBCs at early stages showed excellent outcomes without the need for two-stage surgery. Lymph nodes around the cystic duct were reliable sentinel nodes in suspicious/incidental GBCs. Intentional LN dissection and EHBD resection prevented metastases or recurrence in early-stage GBCs but not in advanced GBCs with metastatic LNs or invasion of the nerve plexus. All patients with positive surgical margins (
CONCLUSION
CONCLUSIONS
Outcomes for GBC patients remain unacceptable, and improved therapeutic strategies, including neoadjuvant chemotherapy, optimal surgery and adjuvant chemotherapy, should be considered for patients with advanced GBCs.
Identifiants
pubmed: 33033570
doi: 10.4254/wjh.v12.i9.641
pmc: PMC7522563
doi:
Types de publication
Journal Article
Langues
eng
Pagination
641-660Informations de copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Références
J Surg Oncol. 2008 Dec 1;98(7):485-9
pubmed: 18802958
Dig Surg. 2019;36(1):7-12
pubmed: 29339658
J Laparoendosc Adv Surg Tech A. 2019 Jun;29(6):741-746
pubmed: 31074684
Surgery. 2014 Mar;155(3):504-11
pubmed: 24287146
Br J Surg. 2000 Apr;87(4):418-22
pubmed: 10759735
Ann Gastroenterol Surg. 2019 Sep 30;3(6):598-605
pubmed: 31788648
Surgery. 2004 Nov;136(5):1012-7; discussion 1018
pubmed: 15523394
Ann Surg Oncol. 2004 Mar;11(3):310-5
pubmed: 14993027
Arch Surg. 2003 Jul;138(7):741-50; discussion 750
pubmed: 12860755
Indian J Cancer. 2016 Oct-Dec;53(4):552-557
pubmed: 28485349
Ann Surg. 2000 Oct;232(4):557-69
pubmed: 10998654
Ann Surg Oncol. 2015 Dec;22 Suppl 3:S336-9
pubmed: 26059653
Mutat Res Rev Mutat Res. 2018 Oct - Dec;778:61-71
pubmed: 30454684
World J Surg. 2015 Jul;39(7):1810-7
pubmed: 25663014
Br J Surg. 2002 Sep;89(9):1130-6
pubmed: 12190678
Ann Surg. 2017 Oct;266(4):625-631
pubmed: 28692469
J Hepatobiliary Pancreat Sci. 2015 Sep;22(9):669-74
pubmed: 25877225
Surg Endosc. 2018 Oct;32(10):4251-4255
pubmed: 29926166
Ann Surg. 2011 Aug;254(2):320-5
pubmed: 21617582
J Gastrointest Cancer. 2018 Mar;49(1):9-15
pubmed: 29234972
Chin Clin Oncol. 2016 Oct;5(5):63
pubmed: 27829277
J Hepatobiliary Pancreat Surg. 2007;14(4):351-7
pubmed: 17653632
Liver Cancer. 2016 Nov;6(1):59-65
pubmed: 27995089
Ann Oncol. 2016 Sep;27(suppl 5):v28-v37
pubmed: 27664259
Ann Surg. 1999 Nov;230(5):663-71
pubmed: 10561090
Ann Surg Oncol. 2014 Dec;21(13):4308-16
pubmed: 25023547
Ann Surg. 2006 Mar;243(3):364-72
pubmed: 16495702
Cochrane Database Syst Rev. 2018 Apr 06;4:CD011746
pubmed: 29624208
World J Surg. 2006 Jul;30(7):1316-20
pubmed: 16830216
Ann Surg Oncol. 2007 Feb;14(2):833-40
pubmed: 17103074
J Hepatobiliary Pancreat Surg. 2007;14(2):131-5
pubmed: 17384902
Surgery. 2000 Feb;127(2):155-60
pubmed: 10686980
Curr Oncol Rep. 2018 Mar 2;20(2):21
pubmed: 29500514
Surgeon. 2016 Dec;14(6):337-344
pubmed: 27395014
Dig Surg. 2019;36(1):1-6
pubmed: 29339660
Ann Surg. 2015 Jul;262(1):121-9
pubmed: 25405563
JAMA Oncol. 2019 Jun 01;5(6):824-830
pubmed: 30998813
J Surg Oncol. 2018 Sep;118(3):477-485
pubmed: 30259519
J Gastrointest Surg. 2007 Nov;11(11):1478-86; discussion 1486-7
pubmed: 17846848
Ann Surg Oncol. 2009 Apr;16(4):806-16
pubmed: 18985272
Eur J Surg Oncol. 2011 Jun;37(6):505-12
pubmed: 21514090
Zentralbl Chir. 2014 Dec;139 Suppl 2:e43-8
pubmed: 21365537
World J Gastroenterol. 2012 Sep 14;18(34):4736-43
pubmed: 23002343
Ann Surg. 2004 Aug;240(2):205-13
pubmed: 15273542
Br J Surg. 2019 Apr;106(5):626-635
pubmed: 30762874
Saudi J Gastroenterol. 2010 Jul-Sep;16(3):161-7
pubmed: 20616410
J Hepatobiliary Pancreat Sci. 2018 Feb;25(2):131-141
pubmed: 29117469
Surgery. 2005 Feb;137(2):148-55
pubmed: 15674194
Ann Surg. 2008 May;247(5):835-8
pubmed: 18438121
J Gastrointest Surg. 2009 Apr;13(4):722-7
pubmed: 19083068
Surg Clin North Am. 2014 Apr;94(2):343-60
pubmed: 24679425
Hepatobiliary Pancreat Dis Int. 2019 Jun;18(3):285-288
pubmed: 31023579
Br J Surg. 2002 Feb;89(2):179-84
pubmed: 11856130
Surg Endosc. 2013 Feb;27(2):406-14
pubmed: 22926892
Surgery. 1996 Nov;120(5):816-21
pubmed: 8909516
Asian Pac J Cancer Prev. 2016;17(4):2137-40
pubmed: 27221908
World J Surg. 2011 Aug;35(8):1887-97
pubmed: 21547420
Hepatogastroenterology. 2012 Oct;59(119):2083-8
pubmed: 22456433
Arq Gastroenterol. 2008 Jan-Mar;45(1):73-81
pubmed: 18425233
J Am Coll Surg. 2017 May;224(5):906-916
pubmed: 28216422
Ann Surg. 2006 Jul;244(1):99-105
pubmed: 16794394
World J Gastroenterol. 2017 Jun 14;23(22):3978-3998
pubmed: 28652652
J Am Coll Surg. 1996 Oct;183(4):345-50
pubmed: 8843263
J Am Coll Surg. 2008 Sep;207(3):371-82
pubmed: 18722943
World J Surg. 1990 Jul-Aug;14(4):535-43; discussion 544
pubmed: 2166381
Br J Surg. 2019 Jan;106(1):32-45
pubmed: 30582640
Ann Surg. 2011 May;253(5):953-60
pubmed: 21490453
J Gastrointest Surg. 2015 Feb;19(2):298-305
pubmed: 25373705
J Clin Oncol. 2012 Jun 1;30(16):1934-40
pubmed: 22529261
Arch Surg. 2011 Jun;146(6):734-8
pubmed: 21690451
J Minim Access Surg. 2018 Apr-Jun;14(2):124-129
pubmed: 28928327
Ann Surg. 2007 Jun;245(6):893-901
pubmed: 17522515
World J Gastroenterol. 2015 Jan 28;21(4):1315-23
pubmed: 25632207
World J Surg. 2008 Apr;32(4):621-6
pubmed: 18224484
Scand J Gastroenterol. 2017 May;52(5):505-514
pubmed: 28270039
J Hepatobiliary Pancreat Sci. 2013 Jun;20(5):518-24
pubmed: 23430053
Langenbecks Arch Surg. 2013 Dec;398(8):1137-44
pubmed: 24057276
Surg Endosc. 2013 Aug;27(8):2821-8
pubmed: 23404149
World J Gastroenterol. 2015 Nov 21;21(43):12211-7
pubmed: 26604631
Cancer Treat Res. ;168:101-20
pubmed: 29206367
World J Gastroenterol. 2011 Jan 14;17(2):174-80
pubmed: 21245989