Link between childhood trauma and psychotic-like experiences in non-affected siblings of schizophrenia patients: A case-control study.
CAPE
childhood trauma
non-affected siblings
psychosis
psychotic-like experiences
schizophrenia
Journal
Early intervention in psychiatry
ISSN: 1751-7893
Titre abrégé: Early Interv Psychiatry
Pays: Australia
ID NLM: 101320027
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
03
08
2020
received:
23
03
2020
accepted:
26
09
2020
pubmed:
10
10
2020
medline:
25
2
2023
entrez:
9
10
2020
Statut:
ppublish
Résumé
Prior research has consistently demonstrated a relationship between childhood trauma (CT) exposure and an increased risk of developing psychotic-like experiences (PLE) and disorders. Studying the link between CT and PLE in non-clinical populations with or without genetic risk factors could help elucidate the etiopathogeny of psychotic disorders, by removing the effect of confounding variables related to psychotic-spectrum illnesses. A total of 60 non-affected siblings of patients with schizophrenia and 75 controls (aged 18-35 years) participated in a cross-sectional survey. The Positive Subscale of Community Assessment of Psychotic Experiences (CAPE) and the CT Questionnaire were used. We found no significant difference with regard to positive dimension of the CAPE between the two groups. Siblings have reported higher CAPE negative symptoms scores than controls (27.9 vs 24.2; P = .015), and more emotional abuse and physical neglect during childhood than controls. After controlling for demographic and psychosocial variables, sexual abuse, emotional neglect and physical neglect were positively related to positive psychotic symptoms in the control group, whereas no dimension of CT has been linked to these symptoms in the sibling group. The link between CT and psychosis seems to be complex, not only dependent on genetic vulnerability or early environmental factors shared by siblings of patients with psychotic disorders, but also several other confounding factors, including other psychopathological symptoms. Prevention strategies for individuals at genetic risk of psychosis should pay particular attention to CT as a potential predictor of sub-clinical depression and psychosis.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1154-1166Informations de copyright
© 2020 John Wiley & Sons Australia, Ltd.
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