Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons.
MPP6
genome-wide association study
sleep centers
sleep quality
Journal
Sleep
ISSN: 1550-9109
Titre abrégé: Sleep
Pays: United States
ID NLM: 7809084
Informations de publication
Date de publication:
12 03 2021
12 03 2021
Historique:
received:
20
02
2020
revised:
28
08
2020
pubmed:
10
10
2020
medline:
27
4
2021
entrez:
9
10
2020
Statut:
ppublish
Résumé
Poor sleep quality can have harmful health consequences. Although many aspects of sleep are heritable, the understandings of genetic factors involved in its physiology remain limited. Here, we performed a genome-wide association study (GWAS) using the Pittsburgh Sleep Quality Index (PSQI) in a multi-ethnic discovery cohort (n = 2868) and found two novel genome-wide loci on chromosomes 2 and 7 associated with global sleep quality. A meta-analysis in 12 independent cohorts (100 000 individuals) replicated the association on chromosome 7 between NPY and MPP6. While NPY is an important sleep gene, we tested for an independent functional role of MPP6. Expression data showed an association of this locus with both NPY and MPP6 mRNA levels in brain tissues. Moreover, knockdown of an orthologue of MPP6 in Drosophila melanogaster sleep center neurons resulted in decreased sleep duration. With convergent evidence, we describe a new locus impacting human variability in sleep quality through known NPY and novel MPP6 sleep genes.
Identifiants
pubmed: 33034629
pii: 5920163
doi: 10.1093/sleep/zsaa211
pmc: PMC7953222
pii:
doi:
Substances chimiques
MPP6 protein, human
0
Membrane Proteins
0
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : HHSN268201000031C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800012C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL046380
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL113338
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC65236
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC65235
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201200008C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC65233
Pays : United States
Organisme : NIMHD NIH HHS
ID : HHSN268201800013I
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC65237
Pays : United States
Organisme : NIDCR NIH HHS
ID : K12 DE022793
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS045685
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201300005I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201200008I
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201300004I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201000021C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC65234
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135818
Pays : United States
Informations de copyright
© Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.
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