Stop COVID Cohort: An Observational Study of 3480 Patients Admitted to the Sechenov University Hospital Network in Moscow City for Suspected Coronavirus Disease 2019 (COVID-19) Infection.
COVID-19
Russia
SARS-CoV-2
cohort
mortality risk factors
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
received:
14
07
2020
pubmed:
10
10
2020
medline:
6
7
2021
entrez:
9
10
2020
Statut:
ppublish
Résumé
The epidemiology, clinical course, and outcomes of patients with coronavirus disease 2019 (COVID-19) in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically diagnosed COVID-19 in real-life settings is lacking. We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow between 8 April and 28 May 2020. Of the 4261 patients hospitalized for suspected COVID-19, outcomes were available for 3480 patients (median age, 56 years; interquartile range, 45-66). The most common comorbidities were hypertension, obesity, chronic cardiovascular disease, and diabetes. Half of the patients (n = 1728) had a positive reverse transcriptase-polymerase chain reaction (RT-PCR), while 1748 had a negative RT-PCR but had clinical symptoms and characteristic computed tomography signs suggestive of COVID-19. No significant differences in frequency of symptoms, laboratory test results, and risk factors for in-hospital mortality were found between those exclusively clinically diagnosed or with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR. In a multivariable logistic regression model the following were associated with in-hospital mortality: older age (per 1-year increase; odds ratio, 1.05; 95% confidence interval, 1.03-1.06), male sex (1.71; 1.24-2.37), chronic kidney disease (2.99; 1.89-4.64), diabetes (2.1; 1.46-2.99), chronic cardiovascular disease (1.78; 1.24-2.57), and dementia (2.73; 1.34-5.47). Age, male sex, and chronic comorbidities were risk factors for in-hospital mortality. The combination of clinical features was sufficient to diagnose COVID-19 infection, indicating that laboratory testing is not critical in real-life clinical practice.
Sections du résumé
BACKGROUND
The epidemiology, clinical course, and outcomes of patients with coronavirus disease 2019 (COVID-19) in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically diagnosed COVID-19 in real-life settings is lacking.
METHODS
We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow between 8 April and 28 May 2020.
RESULTS
Of the 4261 patients hospitalized for suspected COVID-19, outcomes were available for 3480 patients (median age, 56 years; interquartile range, 45-66). The most common comorbidities were hypertension, obesity, chronic cardiovascular disease, and diabetes. Half of the patients (n = 1728) had a positive reverse transcriptase-polymerase chain reaction (RT-PCR), while 1748 had a negative RT-PCR but had clinical symptoms and characteristic computed tomography signs suggestive of COVID-19. No significant differences in frequency of symptoms, laboratory test results, and risk factors for in-hospital mortality were found between those exclusively clinically diagnosed or with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR. In a multivariable logistic regression model the following were associated with in-hospital mortality: older age (per 1-year increase; odds ratio, 1.05; 95% confidence interval, 1.03-1.06), male sex (1.71; 1.24-2.37), chronic kidney disease (2.99; 1.89-4.64), diabetes (2.1; 1.46-2.99), chronic cardiovascular disease (1.78; 1.24-2.57), and dementia (2.73; 1.34-5.47).
CONCLUSIONS
Age, male sex, and chronic comorbidities were risk factors for in-hospital mortality. The combination of clinical features was sufficient to diagnose COVID-19 infection, indicating that laboratory testing is not critical in real-life clinical practice.
Identifiants
pubmed: 33035307
pii: 5920244
doi: 10.1093/cid/ciaa1535
pmc: PMC7665333
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-11Subventions
Organisme : Russian Foundation for Basic Research
ID : 20-04-60063
Investigateurs
Anna Berbenyuk
(A)
Polina Bobkova
(P)
Semyon Bordyugov
(S)
Aleksandra Borisenko
(A)
Ekaterina Bugaiskaya
(E)
Olesya Druzhkova
(O)
Dmitry Eliseev
(D)
Yasmin El-Taravi
(Y)
Natalia Gorbova
(N)
Elizaveta Gribaleva
(E)
Rina Grigoryan
(R)
Shabnam Ibragimova
(S)
Khadizhat Kabieva
(K)
Alena Khrapkova
(A)
Natalia Kogut
(N)
Karina Kovygina
(K)
Margaret Kvaratskheliya
(M)
Maria Lobova
(M)
Anna Lunicheva
(A)
Anastasia Maystrenko
(A)
Daria Nikolaeva
(D)
Anna Pavlenko
(A)
Olga Perekosova
(O)
Olga Romanova
(O)
Olga Sokova
(O)
Veronika Solovieva
(V)
Olga Spasskaya
(O)
Ekaterina Spiridonova
(E)
Olga Sukhodolskaya
(O)
Shakir Suleimanov
(S)
Nailya Urmantaeva
(N)
Olga Usalka
(O)
Margarita Zaikina
(M)
Anastasia Zorina
(A)
Nadezhda Khitrina
(N)
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : ErratumIn
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.