The role of faecal microbiota transplantation in the treatment of inflammatory bowel disease.
Journal
Current opinion in pharmacology
ISSN: 1471-4973
Titre abrégé: Curr Opin Pharmacol
Pays: England
ID NLM: 100966133
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
20
05
2020
revised:
19
07
2020
accepted:
20
08
2020
pubmed:
10
10
2020
medline:
14
10
2021
entrez:
9
10
2020
Statut:
ppublish
Résumé
Faecal microbiota transplantation (FMT) has emerged as a potent form of therapeutic microbial manipulation. There is much interest in exploring its potential in conditions such as inflammatory bowel disease (IBD) where disturbances in the gastrointestinal microbiota play a crucial role in disease pathogenesis. There are 4 randomized controlled trials of FMT as induction therapy in ulcerative colitis, with meta-analyses suggesting significant benefit over placebo. Allied microbial studies have identified potential microbial and metabolic predictors of therapeutic efficacy and highlighted the importance of optimizing future donor and patient selection. Recent literature has evaluated the use of complementary microbial manipulation through pre-antibiotics to improve treatment efficacy. Studies have also assessed the durability of FMT response and its use in maintenance therapy of UC. While data on FMT are more limited in Crohn's disease and pouchitis, cohort and pilot randomized controlled data a now also emerging in these areas.
Identifiants
pubmed: 33035780
pii: S1471-4892(20)30060-6
doi: 10.1016/j.coph.2020.08.009
pmc: PMC7538387
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
8-16Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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