Biopsy-Controlled Non-Invasive Quantification of Collagen Type VI in Kidney Transplant Recipients: A Post-Hoc Analysis of the MECANO Trial.
collagen type VI
extracellular matrix
fibrosis
inflammation
kidney transplantation
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
07 Oct 2020
07 Oct 2020
Historique:
received:
18
09
2020
revised:
30
09
2020
accepted:
02
10
2020
entrez:
10
10
2020
pubmed:
11
10
2020
medline:
11
10
2020
Statut:
epublish
Résumé
The PRO-C6 assay, a reflection of collagen type VI synthesis, has been proposed as a non-invasive early biomarker of kidney fibrosis. We aimed to investigate cross-sectional and longitudinal associations between plasma and urine PRO-C6 and proven histological changes after kidney transplantation. The current study is a post-hoc analysis of 94 participants of the MECANO trial, a 24-month prospective, multicenter, open-label, randomized, controlled trial aimed at comparing everolimus-based vs. cyclosporine-based immunosuppression. PRO-C6 was measured in plasma and urine samples collected 6 and 24 months post-transplantation. Fibrosis was evaluated in biopsies collected at the same time points by Banff interstitial fibrosis/tubular atrophy (IF/TA) scoring and collagen staining (Picro Sirius Red; PSR); inflammation was evaluated by the tubulo-interstitial inflammation score (ti-score). Linear regression analyses were performed. Six-month plasma PRO-C6 was cross-sectionally associated with IF/TA score (Std. β = 0.34), and prospectively with 24-month IF/TA score and ti-score (Std. β = 0.24 and 0.23, respectively) (
Identifiants
pubmed: 33036366
pii: jcm9103216
doi: 10.3390/jcm9103216
pmc: PMC7600059
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Netherlands Organization For Health Research And Development
ID : 114021010
Organisme : Danish Research Fund
ID : Na
Organisme : Novartis Pharma
ID : Na
Organisme : Chilean National Commission of scientific and technological investigation (CONICYT)
ID : F 72190118
Organisme : Graduate School of Medical Sciences of the University Medical Center Groningen
ID : Na
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