Conversion of Germ Cells to Somatic Cell Types in
C. elegans
chromatin
epigenetics
germ cell
germline
reprogramming
Journal
Journal of developmental biology
ISSN: 2221-3759
Titre abrégé: J Dev Biol
Pays: Switzerland
ID NLM: 101613409
Informations de publication
Date de publication:
07 Oct 2020
07 Oct 2020
Historique:
received:
17
09
2020
revised:
02
10
2020
accepted:
06
10
2020
entrez:
10
10
2020
pubmed:
11
10
2020
medline:
11
10
2020
Statut:
epublish
Résumé
The potential of a cell to produce all types of differentiated cells in an organism is termed totipotency. Totipotency is an essential property of germ cells, which constitute the germline and pass on the parental genetic material to the progeny. The potential of germ cells to give rise to a whole organism has been the subject of intense research for decades and remains important in order to better understand the molecular mechanisms underlying totipotency. A better understanding of the principles of totipotency in germ cells could also help to generate this potential in somatic cell lineages. Strategies such as transcription factor-mediated reprogramming of differentiated cells to stem cell-like states could benefit from this knowledge. Ensuring pluripotency or even totipotency of reprogrammed stem cells are critical improvements for future regenerative medicine applications. The
Identifiants
pubmed: 33036439
pii: jdb8040024
doi: 10.3390/jdb8040024
pmc: PMC7712076
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : European Research Council
ID : ERC-StG-2014-637530
Pays : International
Références
Nucleic Acids Res. 2019 Dec 2;47(21):11164-11180
pubmed: 31602465
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8305-10
pubmed: 21527717
Genetics. 2019 Jan;211(1):121-139
pubmed: 30425042
Dev Cell. 2009 May;16(5):699-710
pubmed: 19460346
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2305-9
pubmed: 2422655
Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5061-6
pubmed: 11320248
Science. 2006 Feb 10;311(5762):851-3
pubmed: 16469927
Curr Biol. 2014 May 5;24(9):970-5
pubmed: 24746798
Genes Dev. 2007 Jul 1;21(13):1653-74
pubmed: 17606643
Development. 1997 Feb;124(4):925-36
pubmed: 9043073
Development. 1998 Jul;125(13):2451-6
pubmed: 9609828
Science. 2014 Sep 19;345(6203):1515-8
pubmed: 25237104
Stem Cell Reports. 2014 Mar 27;2(4):547-59
pubmed: 24749077
J Biol Chem. 2011 May 20;286(20):17714-21
pubmed: 21454524
Cell Rep. 2012 Nov 29;2(5):1178-86
pubmed: 23103163
Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5408-15
pubmed: 27573846
Nature. 1999 Jul 15;400(6741):284-8
pubmed: 10421373
Nature. 2012 Sep 20;489(7416):447-51
pubmed: 22810588
Cell. 2002 Dec 27;111(7):991-1002
pubmed: 12507426
Nature. 2015 Dec 10;528(7581):218-24
pubmed: 26659182
Curr Protoc Mol Biol. 2015 Jan 05;109:21.29.1-21.29.9
pubmed: 25559105
J Gerontol A Biol Sci Med Sci. 2005 May;60(5):543-8
pubmed: 15972600
Cell Rep. 2014 Oct 23;9(2):443-50
pubmed: 25310986
Chromosoma. 2015 Dec;124(4):429-42
pubmed: 25894967
Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16782-7
pubmed: 17075059
Dev Cell. 2018 Sep 10;46(5):611-626.e12
pubmed: 30078731
Nat Commun. 2019 Mar 20;10(1):1271
pubmed: 30894520
Mech Dev. 2002 Jun;114(1-2):61-9
pubmed: 12175490
J Vis Exp. 2018 Jan 1;(131):
pubmed: 29364230
PLoS Genet. 2011 Mar;7(3):e1001349
pubmed: 21455483
Development. 2009 Apr;136(8):1241-9
pubmed: 19261701
Science. 2011 Jan 21;331(6015):304-8
pubmed: 21148348
Annu Rev Biochem. 2012;81:65-95
pubmed: 22663077
Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11266-71
pubmed: 16051707
Development. 2015 Jan 15;142(2):291-302
pubmed: 25564623
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8884-9
pubmed: 18579787
Worm. 2014 Dec 31;3(4):e982967
pubmed: 26430553
Elife. 2016 Sep 07;5:
pubmed: 27602485
Curr Biol. 2014 Jul 21;24(14):R637-R638
pubmed: 25050955