Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population.
Genetic variants
Glioma
MIR17HG
Prognosis
Susceptibility
Journal
BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800
Informations de publication
Date de publication:
09 Oct 2020
09 Oct 2020
Historique:
received:
21
12
2019
accepted:
15
09
2020
entrez:
10
10
2020
pubmed:
11
10
2020
medline:
16
4
2021
Statut:
epublish
Résumé
lncRNA MIR17HG was upregulated in glioma, and participated in promoting proliferation, migration and invasion of glioma. However, the role of MIR17HG polymorphisms in the occurrence and prognosis of glioma is still unclear. In the study, 592 glioma patients and 502 control subjects were recruited. Agena MassARRAY platform was used to detect the genotype of MIR17HG polymorphisms. Logistic regression analysis was used to evaluate the relationship between MIR17HG single nucleotide polymorphisms (SNPs) and glioma risk by odds ratio (OR) and 95% confidence intervals (CIs). Kaplan-Meier curves, Cox hazards models were performed for assessing the role of these SNPs in glioma prognosis by hazard ratios (HR) and 95% CIs. We found that rs7318578 (OR = 2.25, p = 3.18 × 10 Our study firstly reported that MIR17HG rs7318578 was a risk factor for glioma susceptibility and rs17735387 was associated with the longer survival of glioma among Chinese Han population, which might help to enhance the understanding of MIR17HG gene in gliomagenesis. In subsequent studies, we will continue to collect samples and follow up to further validate our findings and further explore the function of these MIR17HG SNPs in glioma in a larger sample size.
Sections du résumé
BACKGROUND
BACKGROUND
lncRNA MIR17HG was upregulated in glioma, and participated in promoting proliferation, migration and invasion of glioma. However, the role of MIR17HG polymorphisms in the occurrence and prognosis of glioma is still unclear.
METHODS
METHODS
In the study, 592 glioma patients and 502 control subjects were recruited. Agena MassARRAY platform was used to detect the genotype of MIR17HG polymorphisms. Logistic regression analysis was used to evaluate the relationship between MIR17HG single nucleotide polymorphisms (SNPs) and glioma risk by odds ratio (OR) and 95% confidence intervals (CIs). Kaplan-Meier curves, Cox hazards models were performed for assessing the role of these SNPs in glioma prognosis by hazard ratios (HR) and 95% CIs.
RESULTS
RESULTS
We found that rs7318578 (OR = 2.25, p = 3.18 × 10
CONCLUSION
CONCLUSIONS
Our study firstly reported that MIR17HG rs7318578 was a risk factor for glioma susceptibility and rs17735387 was associated with the longer survival of glioma among Chinese Han population, which might help to enhance the understanding of MIR17HG gene in gliomagenesis. In subsequent studies, we will continue to collect samples and follow up to further validate our findings and further explore the function of these MIR17HG SNPs in glioma in a larger sample size.
Identifiants
pubmed: 33036577
doi: 10.1186/s12885-020-07417-9
pii: 10.1186/s12885-020-07417-9
pmc: PMC7547478
doi:
Substances chimiques
MIR17HG, human
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
976Références
Cancer Epidemiol. 2012 Jun;36(3):283-7
pubmed: 22369735
Genes Chromosomes Cancer. 2016 Jan;55(1):3-15
pubmed: 26482321
J Nutr Biochem. 2016 Aug;34:118-25
pubmed: 27289489
J Cell Mol Med. 2018 Oct;22(10):4611-4616
pubmed: 30073755
Prog Neurol Surg. 2018;30:1-11
pubmed: 29241168
Clin Lymphoma Myeloma Leuk. 2019 Jul;19(7):e359-e366
pubmed: 31029648
Cancer Epidemiol Biomarkers Prev. 2018 Apr;27(4):418-428
pubmed: 29382702
CA Cancer J Clin. 2016 Mar-Apr;66(2):115-32
pubmed: 26808342
Neuro Oncol. 2014 Jul;16(7):896-913
pubmed: 24842956
Cell Death Dis. 2019 Jun 11;10(6):454
pubmed: 31186404
Tumour Biol. 2015 Jul;36(7):5369-76
pubmed: 25680407
Onco Targets Ther. 2016 May 06;9:2735-42
pubmed: 27226732
Diagn Pathol. 2013 May 17;8:83
pubmed: 23683922
J Exp Clin Cancer Res. 2019 Jan 28;38(1):37
pubmed: 30691465
Int J Biochem Cell Biol. 2010 Aug;42(8):1348-54
pubmed: 20227518
J Exp Clin Cancer Res. 2018 Oct 11;37(1):246
pubmed: 30305135
PLoS One. 2018 Jan 19;13(1):e0190515
pubmed: 29351283
Mol Genet Genomic Med. 2019 Jun;7(6):e667
pubmed: 30941921
Nat Rev Dis Primers. 2015 Jul 16;1:15017
pubmed: 27188790
J Cancer Res Clin Oncol. 2015 Oct;141(10):1739-47
pubmed: 25702101
Am J Epidemiol. 2011 Apr 15;173(8):915-22
pubmed: 21350045
Genes Chromosomes Cancer. 2016 May;55(5):460-71
pubmed: 26773734
Nucleic Acids Res. 2010 Sep;38(17):5919-28
pubmed: 20466808
Methods Mol Biol. 2017;1492:77-94
pubmed: 27822857
Oncotarget. 2016 Jul 5;7(27):41737-41747
pubmed: 27229531
J Neurooncol. 2015 Aug;124(1):57-64
pubmed: 26017031