Quantitative analysis of mRNA expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in human livers.

Adult Aged Aldo-Keto Reductases / genetics Biological Variation, Individual Female Gene Expression Regulation, Enzymologic Humans Isoenzymes Liver / enzymology Male Middle Aged RNA, Messenger / genetics Short Chain Dehydrogenase-Reductases / genetics
Human liver Interindividual variability Reductase mRNA

Journal

Drug metabolism and pharmacokinetics
ISSN: 1880-0920
Titre abrégé: Drug Metab Pharmacokinet
Pays: England
ID NLM: 101164773

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 21 07 2020
revised: 14 08 2020
accepted: 19 08 2020
pubmed: 11 10 2020
medline: 25 8 2021
entrez: 10 10 2020
Statut: ppublish

Résumé

The aldo-keto reductase (AKR) and short-chain dehydrogenase/reductase (SDR) superfamilies are responsible for the reduction in compounds containing the aldehyde, ketone, and quinone groups. In humans, 12 AKR isoforms (AKR1A1, AKR1B1, AKR1B10, AKR1B15, AKR1C1, AKR1C2, AKR1C3, AKR1C4, AKR1D1, AKR1E2, AKR7A2, and AKR7A3) and 6 SDR isoforms (CBR1, CBR3, CBR4, HSD11B1, DHRS4, and DCXR) have been found to catalyze the reduction in xenobiotics, but their hepatic expression levels are unclear. The purpose of this study is to determine the absolute mRNA expression levels of these 18 isoforms in the human liver. In 22 human livers, all isoforms, except for AKR1B15, are expressed, and AKR1C2 (on average 1.6 × 10

Identifiants

DOI: 10.1016/j.dmpk.2020.08.004 PMID: 33036882
pubmed: 33036882
pii: S1347-4367(20)30408-0
doi: 10.1016/j.dmpk.2020.08.004
pii:
doi:

Substances chimiques

Isoenzymes 0
RNA, Messenger 0
Aldo-Keto Reductases EC 1.1.1.-
Short Chain Dehydrogenase-Reductases EC 1.1.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

539-547

Informations de copyright

Copyright © 2020 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that there are no conflicts of interest.

Auteurs

Keito Amai (K)

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

Tatsuki Fukami (T)

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan; WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

Hiroyuki Ichida (H)

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

Akiko Watanabe (A)

Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. Tokyo, Japan.

Masataka Nakano (M)

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan; WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

Kengo Watanabe (K)

Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. Tokyo, Japan.

Miki Nakajima (M)

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan; WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan. Electronic address: nmiki@p.kanazawa-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Quantitative analysis of mRNA expression...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Quantitative analysis of mRNA expression...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Aldo-keto reductases › Quantitative analysis of mRNA expression...
questionsmedicales.fr › Phénomènes biologiques › Variation biologique intra-individuelle › Quantitative analysis of mRNA expression...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes codant pour des enzymes › Quantitative analysis of mRNA expression...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Quantitative analysis of mRNA expression...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Isoenzymes › Quantitative analysis of mRNA expression...
questionsmedicales.fr › Système digestif › Foie › Quantitative analysis of mRNA expression...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Quantitative analysis of mRNA expression...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Quantitative analysis of mRNA expression...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Short chain dehydrogenase-reductases › Quantitative analysis of mRNA expression...