Comparison of surgical and pathological parameters after laparoscopic transperitoneal pelvic/para-aortic lymphadenectomies.


Journal

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
ISSN: 1525-1438
Titre abrégé: Int J Gynecol Cancer
Pays: England
ID NLM: 9111626

Informations de publication

Date de publication:
11 2020
Historique:
received: 28 05 2020
revised: 09 09 2020
accepted: 11 09 2020
pubmed: 11 10 2020
medline: 11 11 2021
entrez: 10 10 2020
Statut: ppublish

Résumé

Lymphadenectomy is an integral part of surgical staging and treatment for patients with gynecologic malignancies. Since its introduction, laparoscopic lymphadenectomy has proved feasible, safe, and oncologically adequate compared with open surgery while morbidity is lower and hospital stay considerably shorter. The aim of this study was to examine if surgical outcomes may be improved after the initial learning curve is complete. An analysis of 2535 laparoscopic pelvic and/or para-aortic lymphadenectomies was performed between July 1994 and March 2018 by one team of gynecologic oncology surgeons but with the consistent supervision of a consultant surgeon. Data were collected prospectively evaluating operative time, intra-operative and post-operative complications, number of lymph nodes, and body mass index (BMI). Previously published data of 650 patients treated after introduction of the method (period 1, 1994-2003) were compared with the latter 524 patients (period 2, 2014-2018). The median age of the 2535 patients was 43 years (IQR 34-57). The most common indication for pelvic and/or para-aortic lymphadenectomy was cervical cancer (n=1893). Operative time for para-aortic lymph node dissection was shorter in period 2 (68 vs 100 min, p<0.001). The number of harvested lymph nodes was increased for pelvic (19.2 (range 2-52) vs 21.9 (range 4-87)) and para-aortic lymphadenectomy (10.8 (range 1-52) vs 14.4 (range 4-64)), p<0.001. BMI did not have a significant influence on node count or operative time, with BMI ranging from 14.6 to 54.1 kg/m In this large cohort of patients who underwent laparoscopic transperitoneal lymphadenectomy, lymph node count and peri-operative complications improved after the initial learning curve.

Identifiants

pubmed: 33037104
pii: ijgc-2020-001677
doi: 10.1136/ijgc-2020-001677
doi:

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1798-1802

Informations de copyright

© IGCS and ESGO 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Anna Jacob (A)

Department of Special Operative and Oncologic Gynecology, Asklepios Klinik Altona, Hamburg, Germany an.jacob@asklepios.com.

Andrea Plaikner (A)

Department of Special Operative and Oncologic Gynecology, Asklepios Klinik Altona, Hamburg, Germany.

Achim Schneider (A)

Center for Dysplasia and Cytology, MVZ Fürstenbergkarree Berlin, Berlin, Germany.

Giovanni Favero (G)

Gynecology and Obstetrics, Asklepios Klinik Lich GmbH, Lich, Hessen, Germany.

Roberto Tozzi (R)

Department of Gynaecologic Oncology, Oxford University, Oxford, Oxfordshire, UK.

Peter Mallmann (P)

Department of Gynecology, Medical Faculty of the University of Cologne, Koln, Nordrhein-Westfalen, Germany.

Christian Domröse (C)

Department of Gynecology, Medical Faculty of the University of Cologne, Koln, Nordrhein-Westfalen, Germany.

Peter Martus (P)

Institute for Clinical Epidemiology and Biometry, Eberhard Karls University Tübingen Faculty of Medicine, Tubingen, Baden-Württemberg, Germany.

Simone Marnitz (S)

Department of Radiooncology, Medical Faculty of the University of Cologne, Cologne, Nordrhein-Westfalen, Germany.

Jana Barinoff (J)

Department of Gynecology and Obstetrics, Sankt Gertrauden Krankenhaus GmbH, Berlin, Berlin, Germany.

Christhardt Kohler (C)

Department of Special Operative and Oncologic Gynecology, Asklepios Klinik Altona, Hamburg, Germany.
Department of Gynecology, University of Cologne, Koln, Germany.

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Classifications MeSH