Modulation of cognition and neuronal plasticity in gain- and loss-of-function mouse models of the schizophrenia risk gene Tcf4.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
09 10 2020
09 10 2020
Historique:
received:
25
03
2020
accepted:
21
08
2020
revised:
12
08
2020
entrez:
10
10
2020
pubmed:
11
10
2020
medline:
22
6
2021
Statut:
epublish
Résumé
The transcription factor TCF4 was confirmed in several large genome-wide association studies as one of the most significant schizophrenia (SZ) susceptibility genes. Transgenic mice moderately overexpressing Tcf4 in forebrain (Tcf4tg) display deficits in fear memory and sensorimotor gating. As second hit, we exposed Tcf4tg animals to isolation rearing (IR), chronic social defeat (SD), enriched environment (EE), or handling control (HC) conditions and examined mice with heterozygous deletion of the exon 4 (Tcf4Ex4δ
Identifiants
pubmed: 33037178
doi: 10.1038/s41398-020-01026-7
pii: 10.1038/s41398-020-01026-7
pmc: PMC7547694
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
343Références
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